Changes of gastric and intestinal blood flow, serum phospholipase A2 and interleukin-1β in rats with acute necrotizing pancreatitis

Table 1 Histological grading of gastric mucosal damage.

Grade	Histological appearance
0	No lesion
1	Lesion of mucosal surface, undamaged gastric pit cells
2	Damage involving gastric pits, undamaged gastric gland cells
3	Lesion of gastric gland cells
4	Partial mucosal necrosis, multiple linear ulcer and hemorrhage
5	Total mucosal necrosis

Table 2 Histological grading of intestinal mucosal damage.

Grade	Histological appearance
0	Normal
1	Subepithelial edema, partial separation of apical cells
2	Epithelial cell slough from tips of villi
3	Progression of slough to base of villi
4	Partial mucosal necrosis of lamina propria
5	Total mucosal necrosis

Table 3 Change of gastric and intestinal blood flow [mL/(min·g)] (mean±SD, n = 8).

Group	Stomach		Intestine
	2 h	12 h	2 h	12 h
Control	0.86±0.11	0.85±0.06	1.56±0.18	1.61±0.11
ANP	0.62±0.06b	0.35±0.05b	0.80±0.07b	0.50±0.06b

^bP<0.01 vs control group.

Table 4 PLA₂ activity and IL-1β level in each group (mean±SD, n = 8).

Group	PLA2 (U/L)		IL-1β (ng/mL)
	2 h	12 h	2 h	12 h
Control	65.27±10.52	66.63±9.81	0.32±0.06	0.33±0.07
ANP	94.29±9.96b	103.71±14.40b	0.78±0.13b	0.83±0.20b

^bP<0.01 vs control group.

Table 5 Gastric and intestinal mucosal injury in each group (n = 8).

Group	Stomach												Intestine
	2 h						12 h						2 h						12 h
	0	I	II	III	IV	V	0	I	II	III	IV	V	0	I	II	III	IV	V	0	I	II	III	IV	V
Control	8	0	0	0	0	0	8	0	0	0	0	0	6	2	0	0	0	0	6	2	0	0	0	0
ANP	0	0	2	3	3	0b	0	0	0	1	3	4b	0	0	2	4	2	0b	0	0	0	0	3	5b

^bP<0.01 vs control group.