Effects of Changtai granules, a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats

Table 1 Criteria for scoring the gross morphologic damage.

Score	Gross morphology
0	No damage
1	Localized hyperemia with no ulcers
2	Liner ulcers with no significant inflammation
3	Liner ulcers with inflammation at one site
4	More ulcerative and inflammatory sites, the size of ulcers <1 cm
5	Multiple inflammations and ulcers, the size of ulcers ≥1 cm

Table 2 Effects of CTG on diarrhea frequency and mortality of UC rats.

Group	Dose(g crude drug/kg)	n	Diarrhea				Mortality
			D 1	D 8	D 15	D 22
Normal	-	20	0	0	0	0	0
Model	-	20	20b	10b	7b	2	2
DX	0.2 (mg/kg)	20	20	3a	5	1	4
CTG	2.9	20	20	2d	2	0	0
CTG	5.7	20	20	3a	1a	0	0
CTG	11.4	20	20	1d	0d	0	0

^bP<0.01 vs normal,

^aP<0.05,

^dP<0.01 vs model.

Table 3 Effects of CTG on the weight of UC rats (n = 20).

Group	Dose (g crude drug/kg)	Weight (g)
		D 1	D 8	D 15	D 22
Normal	-	188±13	228±30	253±39	283±50
Model	-	188±10	204±24b	236±26	275±37
DX	0.2 (mg/kg)	189±10d	183±12d	185±8d	191±12d
CTG	2.9	184±16	199±28	227±35	264±41
CTG	5.7	191±11	204±13	238±23	272±34
CTG	11.4	182±9	201±23	232±35	264±42

^bP<0.01 vs normal,

^dP<0.01 vs model.

Table 4 Effects of CTG on colon mass, ulcer, MPO of colon mucosa of UC rats (n = 10).

Group	Dose (g crude drug/kg)	Colon mass index (mg/g)	Colon damage score	MPO (U/g)
Normal	-	3.2±0.6	0 (0-0)	0.17±0.11
Model	-	5.2±1.4d	5 (3-5)d	2.57±1.75d
DX	0.2 (mg/kg)	6.1±4.0	5 (0-5)b	0.80±1.00a
CTG	2.9	4.5±2.4	3 (2-5)b	0.60±0.61b
CTG	5.7	4.0±1.1a	3 (2-4)b	0.48±0.46b
CTG	11.4	3.8±0.5b	2 (0-3)b	0.47±0.36b

^aP<0.05,

^bP<0.01 vs model,

^dP<0.01 vs normal.