Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26

Table 1 H pylori serology (as determined with Cobas^® and pylori DTect ELISA kits), gender, and seroprevalence in the DMHDS at ages 21 and 26.

Test	Age (yr)	n	Seropositivity		Seronegativity		Seroprevalence (95%CI)
			Males	Females	Males	Females
Cobas	21	785	24	8	389	364	4.1 (2.7-5.5)
DTect	21	764	15	5	387	357	2.6 (1.5-3.7)
Both tests	21	795	24	9	394	368	4.2 (2.8-5.5)
Cobas	26	854	32	15	412	395	5.5 (4.0-7.0)
DTect	26	870	28	14	422	406	4.8 (3.4-6.2)
Both tests	26	871	35	20	416	400	6.3 (4.7-7.9)

Table 2 Seropositivity of H pylori infection in the DMHDS at age 26 in relation to risk factors.

	n	Number of seropositivities (%)	Significance by χ2-test
Gender
Male	451	35 (7.8)	0.069
Female	420	20 (4.8)
SES at age 5
High	580	37 (6.4)	NS
Low	237	15 (6.3)
Daily smokers
Yes	343	26 (7.6)	NS
No	528	29 (5.5)
Secondary school qualifications
Yes	704	42 (5.6)	0.042
No	112	13 (10.4)
Employment
Yes	654	44 (6.7)	NS
No	217	11 (5.1)

Table 3 Distribution of categories of H pylori serological status in the DMHDS between ages 21 and 26 (n = 755 , %). Seropositive status is indicated by “+”; seronegative status by “-”.

Status at ages		Males (n = 401)	Females (n = 354)	Total (n = 755)
21	26
+	+	20 (5.0)	8 (2.3)	28 (3.7)
+	-	4 (1.0)	0 (0)	4 (0.5)
-	+	11 (2.7)	9 (2.5)	20 (2.6)
-	-	366 (91.3)	337 (95.2)	703 (93.1)

Table 4 Distribution of categories of H pylori serological status in the DMHDS across ages 11, 21, and 26 (n = 452 , %). Seropositive status is indicated by “+”; seronegative status by “-”.

Status at ages			Males (n = 256)	Females (n = 196)	Total (n = 452)
11	21	26
+	+	+	11 (4.3)	2 (1.0)	13 (2.9)
+	+	-	0 (0)	0 (0)	0 (0)
+	-	+	0 (0)	2 (1.0)	2 (0.4)
+	-	-	6 (2.3)	8 (4.1)	14 (3.1)
-	+	+	3 (0.5)	1 (1.2)	4 (0.9)
-	+	-	1 (0.4)	0 (0)	1 (0.2)
-	-	+	4 (1.6)	4 (2.0)	8 (1.8)
-	-	-	231 (90.2)	179 (91.3)	410 (90.7)