Clinical significance of granuloma in Crohn’s disease

Table 1 Clinical characteristics of patients (mean±SD).

	Patients with granuloma Group I	Patients without granuloma Group II	Significance
Number of patients	25	31	NS
Female/male ratio (No.)	15/10	16/15	NS
Median age (yr)	29.60±11.32	36.46±12.94	NS
Localization
Small bowel only	1 (4%)	4 (12.9%)	NS
Large bowel only	10 (40%)	8 (25.8%)	NS
Small and large bowel	10 (40%)	17 (54.8%)	NS
UGT involvement	4 (16%)	2 (6.4%)	P<0.05
Disease behavior type
Inflammatory	8 (32%)	15 (48.4%)	NS
Stricturing	6 (24%)	9 (29.0%)	NS
Penetrating	11 (44%)	7 (22.6%)	NS
Activity of CD
CDAI	218.9±108.2	144.1±92.5	P = 0.01
Endoscopic scores	6.60±3.53	5.35±4.20	NS

UGT = upper gastrointestinal tract.

Table 2 Frequency of different extraintestinal manifestations in patients with or without granuloma.

	Patients with granuloma (%)	Patients without granuloma (%)	Significance
Number of extraintestinal manifestations	10/25 (40)	7/31 (22.6)	P = NS
Arthritis	6/25 (24)	4/31 (12.9)	P = NS
Eye manifestation	0/25	1/31 (3.2)	P = NS
Cutan manifestation	2/25 (8)	0/31	P = NS
Aphtous stomatitis	2/25 (8)	2/31 (6.4)	P = NS

NS = non-significant.

Table 3 Frequency of relapses in the two groups.

Number of relapse after the succesfull treatment of fist attack	Patients with granuloma (25) (%)	Patients without granuloma (31) (%)
0	5 (20)	12 (38.7)
1	10 (40)	15 (48.4)
2	7 (28)	4 (12.9)
3	3 (12)	0 (0)

Trend -P = 0.06, χ² test.