Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis

Table 1 Demographics and baseline characteristics of erosive esophagitis patients treated with esomeprazole or omeprazole (mean±SE).

	Esomeprazole 40 mg n = 25	Omeprazole 20 mg n = 23	P
Age (yr)	49.2±3.7	59.0±3.4	0.0596
Sex (male%)	20 (80)	18 (78.3)	1.0000
Body weight (kg)	68.4±2.4	70.9±2.5	0.4779
Height (cm)	166.7±1.3	169.0±1.4	0.2096
Basal reflux symptoms (VAS)
Heartburn	29.4±5.7	23.6±5.9	0.2683
Nausea	18.7±5.5	13.8±5.8	0.8520
Regurgitation	29.8±6.1	24.5±6.4	0.3365
Vomiting	14.0±4.7	8.8±4.9	0.5702
Belching	47.0±6.0	25.2±6.3	0.0121
Dysphagia	7.5±5.0	14.7±5.2	0.7421
Epigastric pain	15.8±5.5	16.7±5.8	0.9223
LA grade of erosive esophagitis [n (%)]			0.6617
A	15 (60)	11 (47.8)
B	7 (28)	7 (30.4)
C	2 (8)	2 (8.7)
D	1 (4)	3 (13.0)
Hp infection status	10 (40)	11 (47.8)	0.5643

VAS: visual analog scale, scored from 0 (none) to 100 (most severe); Hp: Helicobacter pylori; LA: Los Angeles.

Table 2 Changes of reflux symptoms assessed on visual analog scale of studied patients 8 wk after esomeprazole or omeprazole treatment (mean±SE).

Reflux symptoms	Esomeprazole n = 22	Omeprazole n = 22	P
Heartburn	-22.3±2.1	-21.4±2.2	0.5453
Nausea	-11.9±2.2	-12.7±2.4	0.8867
Regurgitation	-22.4±2.2	-20.4±2.3	0.8598
Vomiting	-9.1±1.61	-8.8±1.7	0.4438
Belching	-24.1±4.3	-17.9±4.6	0.0113
Dysphagia	-8.4±1.4	-6.5±1.5	0.8044
Epigastric pain	-10.6±2.0	-11.1±2.1	0.1747

VAS was scored from 0 (none) to 100 (most severe).

Table 3 Changed reflux symptoms of studied patients 8 wk after esomeprazole or omeprazole treatment (%).

		Esomeprazole (n = 22)	Omeprazole (n = 20)	P
Heartburn	Improved	50.0	65.0	0.0993
	No change	50.0	25.0
	Worse	0.0	10
Regurgitation	Improved	77.3	85.0	1.0000
	No change	18.2	15.0
	Worse	4.5	0.0
Dysphagia	Improved	36.4	35.0	0.8697
	No change	63.6	60.0
	Worse	0.0	5
Epigastric pain	Improved	27.3	50.0	0.1895
	No change	63.6	50.0
	Worse	9.1	0.0
Nausea	Improved	22.7	35.0	0.5036
	No change	68.2	65.0
	Worse	9.1	0
Vomiting	Improved	22.7	40.0	0.3200
	No change	77.3	60.0
	Worse	0.0	0.0
Belching	Improved	54.5	45.0	0.8999
	No change	36.4	45.0
	Worse	9.1	10

Table 4 AE in studied patients 8 wk after esomeprazole or omeprazole treatment (ITT).

	Esomeprazole (n = 25) n(%)	Omeprazole (n = 23) n (%)	P
Patient with at least one AE	7 (28.0)	6 (26.1)	1.0000
Constipation	2 (8.0)	1 (4.4)	1.0000
Dry skin	1 (4.0)	3 (13.0)	0.3381
Diarrhea	1 (4.0)	1 (4.4)	1.0000
Headache	1 (4.0)	1 (4.4)	1.0000
Somnolence	1 (4.0)	1 (4.4)	1.0000
Cellulites	0 (0.0)	1 (4.4)	0.4792
Bronchitis	0 (0.0)	1 (4.4)	0.4792