Association of the myeloperoxidase-468G→A polymorphism with gastric inflammation and duodenal ulcer risk

Table 1 Characteristics of DU patients and HCs.

	HCs (n = 182, %)	DU (n = 115, %)	P
Age (yr)	53.414.1	52.914.10	0.755
Sex			0.012
Male	95 (52.2)	77 (67.0)
Female	87 (47.8)	38 (33.0)
Blood group			0.128
A	49 (26.9)	22 (19.1)
B	55 (30.2)	28 (24.3)
O	66 (36.3)	57 (49.6)
AB	12 (6.6)	8 (7.0)
Cigarette smokers	37 (20.3)	38 (33.0)	0.014
Heavy drinkers	7 (3.8)	8 (7.0)	0.233
H pylori infection	87 (47.8)	93 (80.9)	<0.001

Table 2 Genotypes and allele frequencies of myeloperoxidase gene in DU patients and HCs (n, %).

	HCs (n = 182)	DU (n = 115)	P
Genotypes			0.008
G/G	143 (78.6)	84 (73.0)
G/A	39 (21.4)	25 (21.7)
A/A	0 (0.0)	6 (5.2)

Table 3 The myeloperoxidase polymorphism and H pylori infection in the development of DU.

Myeloperoxidaseallele A carrier	H pylori infection	HC (n = 182, %)	DU (n = 115, %)	Odds ratio1(95%CI)	P
(-)	(-)	72 (39.6)	13 (11.3)	-
(+)	(-)	23 (12.6)	9 (7.8)	2.3 (0.8-8.4)	0.1257
(-)	(+)	71 (39.0)	71 (61.7)	5.8 (2.9-11.8)	<0.001
(+)	(+)	16 (8.8)	22 (19.1)	8.7 (3.5-21.8)	<0.001

¹Variables including age, sex and blood group have been adjusted.

Table 4 Comparison of gastric histological findings between DU patients and HCs.

Histological parameters	HCs (n = 11)	DU (n = 49)	P
Antrum	0.55±0.25	1.37±0.14	0.0101
H pylori	0.50±0.27	1.53±0.13	0.0021
Activity	1.60±1.07	2.57±0.12	0.0021
Inflammation	0.20±0.13	1.10±0.11	0.0011
Atrophy	0.00±0.00	0.10±0.05	0.387
Intestinal metaplasia	0.00±0.00	0.49±0.11	0.0401
Lymphoid follicle
Corpus
H pylori	0.27±0.14	0.96±0.14	0.0251
Activity	0.10±0.10	0.73±0.12	0.0211
Inflammation	0.12±0.20	1.96±0.10	0.0031
Atrophy	0.00±0.00	0.23±0.07	0.133
Intestinal metaplasia	0.00±0.00	0.08±0.05	0.454
Lymphoid follicle	0.00±0.00	0.08±0.04	0.33

¹Significant difference.