Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy

Table 1 Serum vitamin B₁₂, folate, erythrocyte folate, and homocysteine levels before and after H pylori eradication treatment (mean±SD).

	Patients with successful eradication (n = 41)
	Before treatment	After treatment	P
Serum vitamin B12 (pg/mL)	210±97	237±94	<0.001
Serum folate (ng/mL)	5.6±2.6	6.0±2.4	0.341
Erythrocyte folate (ng/mL)	442±212	539±304	0.024
Serum homocysteine (mmol/L)	13.1±5.2	11.9±6.2	0.002

Table 2 Relationships between serum homocysteine level and serum or erythrocyte levels of vitamins, and patient age and sex before H pylori eradication.

	Pearson’s r	P
Homocysteine–age	0.272	0.02
Homocysteine–sex	-0.201	0.088
Homocysteine–B12	-0.267	0.023
Homocysteine–serum folate	-0.367	0.001
Homocysteine–erythrocyte folate	-0.336	0.004
Serum folate–erythrocyte folate	0.654	<0.001