Blood platelet and monocyte activations and relation to stages of liver cirrhosis

doi:10.3748/wjg.v11.i18.2754

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May 14, 2005 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. May 14, 2005; 11(18): 2754-2758
Published online May 14, 2005. doi: 10.3748/wjg.v11.i18.2754

Table 1 Blood plt, monocyte serum and cytometric parameters in clinical stages of LC according to Child-Pugh classification.

	Healthy	Cirrhosis hepatitis stage (Child–Pugh)
	Healthy	B	C
Blood plt
Blood plt (1×10³/mL)	219±25	124±77^a	115±66^a
sP-selectin (pg/mL)	133±70	74±42^a	69±35^a
PF4 (IU/mL)	36±7	30±9	26±16
bTG (IU/mL)	128±45	137±40	101±62
CD62P (%)	6±1.8	10±4^a	9.3±3^a
MIF CD62	0.47±0.08	0.66±0.2^a	0.66±0.2^a
CD63 (%)	0.7±0.3	2.2±1.5	1.5±0.9
MIF CD63	0.3±0.04	0.4±0.09^a	0.4±0.07^a
Monocyte
Monocyte (%)	5.7±3.1	6.8±3.3	7.0±2.9
MCP-1 (pg/mL)	218±129	150±93	153±81
MIF CD14	26±2	27±7	26±4
CD16 (%)	2.9±1.6	7.9±7.8^a	8.1±5.2^a
MIF CD16	1.5±0.5	1.9±1.1	2.9±1.5^a
CD11b (%)	100±0.1	99.5±0.8	99.5±2.0^a
MIF CD11	17.4±5.8	18.5±4.8	21.2±5.9^a
Aggregates
Plt–monocytes (%)	13.5±4.0	10.7±5.6	13.6±16.8
MIF CD45 on plt–monocyte aggregates	11.8±3.6	11.6±3.5	15.1±4.5

^aP<0.05 vs Healthy statistical significance in healthy subjects, Mann–Whitney U-test. MIF-medial intensity of fluorescence.

Table 2 Correlations (r) of blood plt count and their activation markers in clinical stages of LC.

	Cirrhosis hepatitis stage (Child–Pugh)
	B	C
sP-selectin	0.61	0.58
MCP-1	0.41	0.39
PF4	-0.42	-0.62
bTG	NS	-0.45
CD62P	-0.53	-0.52
MIF CD62P	NS	-0.52
CD63	-0.58	-0.41
MIF CD63	-0.56	-0.3
Plt–monocyte aggregates	0.77	0.81

There was no correlation in the controls. Spearman’s test, NS – no statistical differences.

Table 3 Correlations (r) of plt-monocytes aggregate level and markers of plt activation (Spearman’s test).

	Healthy	Cirrhosis hepatitis stage (Child-pugh)
	Healthy	B	C
Plt CD62P (%)	NS	0.47^b	0.58^b
MIF CD62P	NS	0.45^b	0.58^b
Plt CD63 (%)	NS	0.3^a	0.49^b
SP-selectin	NS	0.6^b	0.51^b
PF4	NS	NS	0.68^b
βTG	NS	NS	0.44^a

^aP<0.05,

^bP<0.01 vs Healthy NS – no statistical correlations.

Table 4 Correlations (r) of sP-selectin value with monocyte and plt activation markers and other parameters in LC.

	Cirrhosis hepatitis stage (Child-pugh)
	B	C
AST (U/L)	NS	0.56^b
ALT (U/L)	NS	0.41^a
ALP (U/L)	NS	0.42^a
GGT (U/L)	NS	0.54^b
Leukocyte (1×10³/mL)	0.6^a	0.58^b
Monocyte (%)	NS	0.37^a
MIF CD14	0.73^b	NS
MIF CD16	0.3^a	NS
CD62P (%)	0.57^b	NS
MIF CD62P	0.53^b	NS
CD63 (%)	0.54^b	NS
MIF CD63	0.5^a	NS

In healthy subjects we observed no statistical correlations (Spearman’s test).

^aP<0.05,

^bP<0.01 vs other groups NS – no statistical correlations.

Citation: Panasiuk A, Zak J, Kasprzycka E, Janicka K, Prokopowicz D. Blood platelet and monocyte activations and relation to stages of liver cirrhosis. World J Gastroenterol 2005; 11(18): 2754-2758
URL: https://www.wjgnet.com/1007-9327/full/v11/i18/2754.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i18.2754