Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer

doi:10.3748/wjg.v11.i18.2744

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 18

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4534)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

428

HTML

3138

Figures (1-2)

516

Tables (1-2)

452

Sum=4534

May 14, 2005 (publication date) through Oct 30, 2025

Times Cited of This Article

Times Cited (15)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Basic Research

World J Gastroenterol. May 14, 2005; 11(18): 2744-2747
Published online May 14, 2005. doi: 10.3748/wjg.v11.i18.2744

Table 1 pBcl-2 and pBax expression and their relationship with clinicopathological parameters for the patients with pancreatic cancer.

Parameter		No. of patients	Number of pBcl-2 and pBax expressing (%)
Parameter		No. of patients	pBcl-2 (+)	pBcl-2 (-)	PBax (+)	PBax (-)
Overall		59	21 (35.6)	38 (64.4)	29 (49.2)	30 (50.8)
Age (yr)	<65	47	17 (36.2)	30 (63.8)	26 (55.3)	21 (44.7)
	≥65	12	4 (33.3)	8 (66.7)	3 (25)	9 (75)
Gender	Male	38	14 (36.8)	24 (63.2)	18 (47.3)	20 (52.7)
	Female	21	7 (33.3)	14 (66.7)	11 (52.4)	10 (47.6)
TNM stage	I	4	1 (25)	3 (75)	3 (75)	1 (25)
	II	8	5 (62.5)	3 (37.5)	4 (50)	4 (50)
	III	42	14 (33.3)	28 (66.7)	19 (45.2)	23 (54.8)
	IV	5	1 (20)	4 (80)	3 (60)	2 (40)
Grade	Well	19	8 (42.1)	11 (57.9)	11 (57.9)	8 (42.1)
	Moderate	21	8 (38.1)	13 (61.9)	8 (38.1)	13 (61.9)
	Poor	19	5 (26.3)	14 (73.7)	10 (52.6)	9 (47.7)

Full Size Table

Table 2 Correlation between various factors and survival time by Cox proportional hazards model (dependent variable, mo; censoring variable, death due to pancreatic cancer).

Variable	Parameter estimate (SE)	Conditional risk ratio (95% CI)	P (χ²)
Overall pBcl-2	-1.216 (0.340)	0.297 (0.152-0.577)	0.001
(n = 59) TNM	0.582 (0.246)	1.790 (1.104-2.902)	0.018
Age (yr)	0.037 (0.017)	1.038 (1.004-1.073)	0.026
pBax	0.734 (0.360)	2.084 (1.029-4.222)	0.041
Site	-0.566 (0.487)	0.568 (0.219-1.474)	0.245
Grade	0.169 (0.268)	1.184 (0.701-2.001)	0.528
Gender	0.061 (0.352)	1.063 (0.534-2.118)	0.862

Full Size Table

Citation: Dong M, Zhou JP, Zhang H, Guo KJ, Tian YL, Dong YT. Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer. World J Gastroenterol 2005; 11(18): 2744-2747
URL: https://www.wjgnet.com/1007-9327/full/v11/i18/2744.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i18.2744