Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats

Table 1 Islet allograft survival and animal survival in recipients treated with CsA and MMF.

Variable	Group A Controls n = 12	Group B CsA n = 11	Group C MMF n = 11	P x2
3rd-d graft survival (%)	3 (25)	9 (82)	9 (82)	<0.01
Graft survival in days after	0 (1.2)	10 (4.9)	12 (5.1)	Kruskal Wallis
Tx (median SD)				<0.01
Animal survival in days	8.1 (3.7)	12 (0.0)	12 (0.0)	Kruskal Wallis
after Tx (median SD)				<0.01

Tx: transplantation, CsA: cyclosporine A, MMF: mycophenolate mofetil.

Table 2 SGOT, SGPT, γGT and creatinine measurements in the controls as well as in the two therapy groups.

Variable	Group A Controls	Group B CsA	Group C MMF
SGOT (mean, SD)	144 (27.6)	119 (47)	131 (46)
SGPT (mean, SD)	48.4 (12.9)	66 (27)	33 (15)f
gGT (mean, SD)	1.14 (0.42)	2.8 (0.5)b	0.7 (0.5)f
Creatinine (mean, SD)	0.6 (0.16)	0.6 (0.1)	0.4 (0.1)df

^bP<0.01 vs controls,

^dP<0.027 vs controls,

^fP<0.01 vs CsA.

Table 3 Histologic evaluation after transplantation.

Group Animal	CsA Inf/End	MMF Inf/End	Controls Inf/End
1	0/Occasional	0/Occasional	0/Occasional
2	0/Occasional	+/Occasional	+++/None
3	0/Many	+/Occasional	++++/None
4	++++/Occasional	+/Plentiful	++++/None
5	++++/Occasional	+++/Plentiful	++++/None
6	++++/Many	++++/Occasional	++/Occasional
7	++++/Many	++++/Occasional	++/Occasional
8	++++/Many	++++/Occasional	+++/Occasional
9	Necrosis	++++/Occasional	++++/Occasional
10	Necrosis	++++/Occasional	Necrosis
11	Necrosis	Necrosis	Necrosis
12	-	-	Necrosis

Inf: infiltrating cells, End: endocrine cells. Sections with abundant necrosis were not evaluated.