Anti-hepatocarcinoma effects of 5-fluorouracil encapsulated by galactosylceramide liposomes in vivo and in vitro

Table 1 Changes of tumor volume and survival time in TB mice (mean±SD, n = 10).

Groups	Doses (mg/kg)	Tumor volume (cm3)	Tumor inhibition rate (%)	Survival time (d)
Control	-	0.45±0.17	-	26.3±3.2
5-Fu-GCL	20	0.30±0.10a	33.3	29.5±4.2
	40	0.19±0.07bc	57.7	35.9±5.8b
	80	0.12±0.05b	73.3	42.7±6.3b
Free-5-Fu	40	0.27±0.08b	40.0	32.9±5.7a

^aP<0.05,

^bP<0.01 vs control;

^cP<0.05 vs free 5-Fu.

Table 2 Distribution of 5-Fu-GCL in liver tumor (mean±SD, n = 10).

Groups	Doses (mg/kg)	Content (mg/g)
Control	-	-
5-Fu-GCL	20	16.3±3.5
	40	22.9±4.7a
	80	28.3±5.9
Free 5-Fu	40	18.3±3.2

^aP<0.05 vs 5-F-Fu.