Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 28, 2005; 11(16): 2390-2397
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2390
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2390
Number of In-P | Name | Sex | Age (yr) | Pathological diagnosis | Lymph metastasis | Clinical stage |
113702 | Jiang | F | 45 | Lesser curvature of stomach invasion ulcer type moderate differentiation adenocarcinoma invasion serosa | 1/35 | III |
123730 | Xu | M | 48 | Anterior wall in body of stomach moderate differentiation adenocarcinoma invasion muscular layers and nerve | 1/17 | III |
123673 | Tang | F | 57 | Lesser curvature in cardia of stomach invasion ulcer type moderate differentiation adenocarcinoma invasion serosa | 1/14 | III |
123808 | Yu | F | 49 | Anterior wall in cardia of stomach poor-moderate differentiation adenocarcinoma, a part of mucinous adenocarcinoma and esophagus of extremities inferior | 0/35 | II |
123733 | Huang | M | 60 | Cardia of stomach node type moderate differentiation adenocarcinoma invasion muscular layer esophagus | 5/22 | III |
Numbers of genes | Up-regulated | Down-regulated | ||
SLR>2 | SLR>3 | SLR <-2 | SLR <-3 | |
T vs C | 530 | 157 | 236 | 113 |
P vs C | 50 | 17 | 14 | 7 |
T and P vs C | 108 | 21 | 35 | 17 |
Probe Set ID | T vs C SLR | P vs C SLR | Name | GO molecular function |
202580-x-at | 2 | 2.4 | Forkhead box M1 | GO:3702; RNA polymerase II transcription factor activity; traceable author statement |
GO:3700; transcription factor activity; traceable author statement | ||||
203098-at | 2.3 | 2.4 | Chromodomain protein, Y chromosome-like | GO:3682; chromatin binding; inferred from electronic annotation |
GO:3824; enzyme activity; inferred from electronic annotation | ||||
203334-at | 3.1 | 3.8 | DEAD/H (Asp-Glu-Ala-Asp/His) | GO:3723; RNA binding; inferred from electronic annotation box polypeptide 8 (RNA helicase) |
GO:8248; pre-mRNA splicing factor activity; traceable author statement | ||||
GO:5524; ATP binding; inferred from electronic annotation | ||||
GO:4004; ATP dependent RNA helicase activity; traceable author statement | ||||
208152-s-at | 1.9 | 2.1 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 | GO:3723; RNA binding; inferred from electronic annotation |
GO:5524; ATP binding; inferred from electronic annotation | ||||
GO:4004; ATP dependent RNA helicase activity; traceable authorstatemen | ||||
209820-s-at | 2.2 | 2.3 | Transducin (beta)-like 3 | GO:5057; receptor signaling protein activity; predicted/computed |
217173-s-at | 3.4 | 3.6 | Low density lipoprotein receptor (familial hypercholesterolemia) | GO:5041; low-density lipoprotein receptor activity; traceable author statement |
GO:5509; calcium ion binding; inferred from electronic annotation | ||||
GO:8034; lipoprotein binding; traceable author statement | ||||
GO:5319; lipid transporter activity; inferred from electronic | ||||
207102-at | -2.4 | -3.6 | Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | GO:5489; electron transporter activity; experimental evidence |
208580-x-at | -2.7 | -3 | H4 histone family, member E (H4FE) | Unknown |
218730-s-at | -2.5 | -3.3 | Osteoglycin (osteoinductive factor, mimecan) | GO:8083; growth factor activity; inferred from electronic annotation |
Molecular function | Up-regulated (SLR> 2) | Down-regulated (SLR <-2) |
Enzyme activity | 15 | 4 |
Enzyme regular activity | 4 | 0 |
Structural molecule activity | 3 | 1 |
Transcription factor activity | 3 | 0 |
Nucleic acid binding (RNA, DNA) | 16 | 5 |
Protein binding activity (Ca , GF, cell skeleton) | 14 | 7 |
Carbohydrate binding activity | 3 | 0 |
Metal ion binding activity | 1 | 0 |
Signal transduction activity (receptor, GF) | 7 | 3 |
Sport activity | 2 | 1 |
Transporter activity (electron, ion, protein) | 7 | 6 |
Tumor antigen | 2 | 0 |
Tumor suppressor | 3 | 0 |
Apoptosis suppressor | 1 | 0 |
Fibrinogen | 0 | 1 |
Unknown | 27 | 7 |
Total | 108 | 35 |
Probe Set ID | T vs C SLR | P vs C SLR | Name | GO molecular function |
201655-s-at | 3.1 | 2.6 | Heparan sulfate | GO:5198; structural molecule activity; inferred from electronic annotation |
proteoglycan 2 (perlecan) | GO:5206; heparin sulfate proteoglycan; traceable author statement | |||
201890-at | 3.1 | 1.6 | Ribonucleotide reductase | GO:4748; ribonucleoside-diphosphate reductase activity;non-traceable |
M2 polypeptide | author statement | |||
GO:16491; oxidoreductase activity; inferred from electronic annotation | ||||
201926-s-at | 3.1 | 1 | Decay accelerating factor for complement (CD55, Cromer blood group system) | Unknown |
203334-at | 3.1 | 3.8 | DEAD/H (Asp-Glu-Ala—Asp/His) box polypeptide 8(RNA helicase) | GO:3723; RNA binding; inferred from electronic annotation |
GO:8248; pre-mRNA splicing factor activity; traceable author statement | ||||
GO:5524; ATP binding;inferred from electronic annotation | ||||
GO:4004; ATP dependent RNA helicase activity; traceable author statement | ||||
202870-s-at | 3.3 | 1.5 | CDC20 cell division cycle 20 homolog (S. cerevisiae) | Unknown |
209035-at | 3.3 | 1.6 | Midkine (neurite growth- promoting factor 2) | GO:8201; heparin binding; not recorded |
GO:8083; growth factor activity; not recorded | ||||
GO:5125; cytokine activity; not recorded | ||||
209803-s-at | 3.4 | 1.8 | Tumor suppressing subtransferable candidate 3 | Unknown |
212444-at | 3.4 | 1.2 | Homo sapiens, clone IMAGE:4471726, mRNA | Unknown |
217173-s-at | 3.4 | 3.6 | Low density lipoprotein receptor (familial hypercholesterolemia) | GO:5041; low-density lipoprotein receptor activity; traceable author statement |
GO:5509; calcium ion binding; inferred from electronic annotation | ||||
GO:8034; lipoprotein binding; traceable author statement | ||||
GO:5319; lipid transporter activity; inferred from electronic | ||||
217221-x-at | 3.5 | 2.2 | RNA binding motif protein 10 | GO:3676; rrm; nucleic acid binding activity; 8.4e-05; extended: inferred from electronic annotation |
GO:3676; rrm; nucleic acid binding activity; 0.76; extended: inferred from electronic annotation | ||||
202855-s-at | 3.6 | 1.2 | Solute carrier family 16 (monocarboxylic acid transporters), member 3 | GO:8028; monocarboxylic acid transporter activity; traceable author statement |
GO:15355; monocarboxylate porter activity; inferred from electronic annotation | ||||
GO:15293; symporter activity; inferred from electronic annotation | ||||
203559-s-at | 3.6 | 1.2 | Amiloride binding protein 1(amine oxidase (copper-containing)) | GO:8144; drug binding;not recorded |
GO:8201; heparin binding; inferred from electronic annotation | ||||
GO:8122; amine oxidase (copper-containing) activity; inferred from electronic annotation | ||||
GO:16491; oxidoreductase activity; inferred from electronic annotation | ||||
209373-at | 3.8 | 1.6 | BENE protein | Unknown |
203108-at | 4.2 | 1.5 | Retinoic acid induced 3 | GO:8067; metabotropic glutamate, GABA-B-like receptor activity; inferred from electronic annotation |
GO:4872; receptor activity; inferred from electronic annotation | ||||
202067-s-at | 4.5 | 3.8 | Low density lipoprotein receptor (familial hypercholesterolemia) | GO:5041; low-density lipoprotein receptor activity; traceable author statement |
GO:5509; calcium ion binding; inferred from electronic annotation | ||||
GO:8034; lipoprotein binding; traceable author statement | ||||
GO:5319; lipid transporter activity; inferred from electronic | ||||
218900-at | 4.5 | 3.7 | Cyclin M4 | Unknown |
201884-at | 4.6 | 2.1 | Carcinoembryonic antigen-related cell adhesion molecule 5 | GO:8222; tumor antigen; traceable author statement |
211657-at | 5.9 | 2.1 | Carcinoembryonic antigen- related cell adhesion molecule 6 | GO:8222; tumor antigen; traceable author statement |
212768-s-at | 4.7 | 1.3 | Differentially expressed in hematopoietic lineages | Unknown |
208250-s-at | 6.3 | 1.7 | Deleted in malignant brain tumors 1 | GO:8181; tumor suppressor; predicted/computed |
GO:5044; SRCR; scavenger receptor activity; 3.7e-42;extended: unknown | ||||
204855-at | 7.7 | 4.2 | Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin) member 5 | GO:4868; serpin; not recorded GO:4867; serine protease nhibitor activity; inferred from electronic annotation |
GO:8181; tumor suppressor; traceable author statement serp |
Probe Set ID | T vs C SLR | P vs C SLR | Name | GO molecular function |
207102-at | -2.4 | -3.6 | Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5- beta-reductase) | GO:5489; electron transporter activity; experimental evidence |
218730-s-at | -2.5 | -3.3 | Osteoglycin (osteoinductive factor, mimecan) | GO:8083; growth factor activity; inferred from electronic annotation |
204940-at | -3.3 | -1.3 | Phospholamban | GO:42030; ATPase inhibitor activity; inferred from electronic annotation |
GO:5246; calcium channel regulator activity; not recorded | ||||
208281-x-at | -3.3 | -1.1 | Deleted in azoospermia 3 | GO:3676; nucleic acid binding; inferred from electronic annotation |
216351-x-at | -3.3 | -1.6 | Deleted in azoospermia 4 | Unknown |
209894-at | -3.7 | -1.5 | Leptin receptor | GO:4896; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; inferred from electronic annotation |
214723-x-at | -3.7 | -1.5 | KIAA1641 protein | Unknown |
208282-x-at | -4.3 | -1.2 | Deleted in azoospermia 2 | GO:3676; nucleic acid binding; inferred from electronic annotation |
219564-at | -4.3 | -1.2 | Potassium inwardly- rectifying channel, subfamily J, member 16 | GO:5242; inward rectifier potassium channel activity; inferred from electronic annotation |
GO:5244; voltage-gated ion channel activity; inferred from electronic annotation | ||||
GO:5267; potassium channel activity; inferred from electronic annotation | ||||
203571-s-at | -4.8 | -1.6 | Adipose specific 2 | Unknown |
218087-s-at | -5 | -1.3 | Sorbin and SH3 domain containing 1 | GO:8092; cytoskeletal protein binding; experimental evidence |
GO:3779; actin binding; experimental evidence | ||||
207909-x-at | -5.2 | -1.2 | Deleted in azoospermia | GO:3676; rrm; nucleic acid binding activity; 4.3e-10; extended: inferred from electronic annotation |
GO:3723; RNA binding; predicted/computed | ||||
213071-at | -5.3 | -1.3 | Dermatopontin | GO:5515; protein binding; traceable author statement |
GO:5194; cell adhesion molecule activity; inferred from electronic annotation | ||||
201497-x-at | -5.4 | -1 | Myosin, heavy polypeptide 11, smooth muscle | GO:3779; actin binding; inferred from electronic annotation |
GO:5516; calmodulin binding; inferred from electronic annotatio | ||||
GO:5524; ATP binding; inferred from electronic annotation | ||||
GO:3774; motor activity; inferred from electronic annotation | ||||
207912-s-at | -5.9 | -1.3 | Deleted in azoospermia | GO:3676; rrm; nucleic acid binding activity; 4.3e-10;extended:inferred from electronic annotation |
GO:3723; RNA binding;predicted/computed | ||||
220630-s-at | -6.3 | -1.8 | Eosinophil chemotactic cytokine | GO:16787; Glyco_hydro_18; hydrolase activity; 2.7e-81; extended:Unknown |
GO:16798; hydrolase activity, acting on glycosyl bonds;inferred from electronic annotation | ||||
GO:8061; chitin binding;inferred from electronic annotation | ||||
GO:8843; endochitinase activity; inferred from electronic annotation | ||||
209612-s-at | -6.9 | -1.4 | Alcohol dehydrogenase IB (class I), beta polypeptide | GO:4024; alcohol dehydrogenase activity, zinc-dependent;traceable author statement |
GO:4327; 1.2.1.1; formaldehyde dehydrogenase (glutathione) activity; 3.69e-120; extended: inferred from electronic annotation | ||||
GO:4023; alcohol dehydrogenase activity, metal ion- independent; inferred from electronic annotation | ||||
GO:4025; alcohol dehydrogenase activity, iron-dependent;inferred from electronic annotation | ||||
GO:8270; zinc ion binding; traceable author statement | ||||
GO:4552; 1.1.1.73; octanol dehydrogenase activity; 4.76e-120; extended: non-traceable author statement | ||||
GO:16491; oxidoreductase activity; inferred from electronic annotation | ||||
GO: 5489; electron transporter activity; traceable author statement |
- Citation: Yu CD, Xu SH, Mou HZ, Jiang ZM, Zhu CH, Liu XL. Gene expression profile differences in gastric cancer, pericancerous epithelium and normal gastric mucosa by gene chip. World J Gastroenterol 2005; 11(16): 2390-2397
- URL: https://www.wjgnet.com/1007-9327/full/v11/i16/2390.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i16.2390