Esophageal Cancer
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 28, 2005; 11(16): 2385-2389
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2385
Table 1 Characteristics of ESCC, GCA patients, and healthy individuals.
GroupsControl n (%)ESCCn (%)P1GCA n (%)P1
Sex
Male229 (65.4)169 (72.2)0.08134 (73.2)0.07
Female121 (34.6)65 (27.8)49 (26.8)
Mean age51.7 (10.7)54.1 (10.2)0.06155.0 (10.5)0.062
in yr (SD)
Smoking status3
Ex-or current
smoker120 (42.9)96 (50.5)0.1092 (55.4)0.015
Non-smoker160 (57.1)94 (49.5)74 (44.6)
Family history of UGIC4
Positive6 (4.7)56 (30.4)<0.0001662 (39.7)<0.00016
Negative123 (95.3)128 (69.6)96 (60.3)
MMP-1 SNP genotype
2G/2G194 (55.4)130 (55.6)0.61112 (61.2)0.35
1G/2G105 (30.0)76 (32.5)51 (27.3)
1G/1G51 (14.6)28 (11.9)20 (10.9)
MMP-1 SNP allelotype
2G493 (70.4)336 (71.8)0.61275(75.1)0.10
1G207 (29.6)132 (28.2)91 (24.9)
Table 2 Association analysis of the MMP1 SNP with the risk of ESCC and GCA development.
1G/1G2G/2G2G/1G+2G/2GaOR (95%CI)3aOR (95%CI)4
Overall
Normal51 (14.9)194 (55.4)299 (85.4)
ESCC28 (12.0)130 (55.6)206 (88.0)1.28 (0.78-2.09)1.23 (0.38-2.05)
GCA20 (10.9)112 (61.2)163 (89.1)1.39 (0.80-2.41)1.34 (0.74-2.40)
Non-smoker1
Normal25 (15.6)89 (55.6)135 (84.4)
ESCC10 (10.6)58 (61.7)84 (89.4)1.55 (0.65-3.46)1.54 (0.68-3.48)
GCA10 (13.5)40 (54.1)64 (86.5)1.12 (0.49-2.58)1.20 (0.38-3.82)
Smoker
Normal18 (15.0)64 (53.3)102 (85.0)
ESCC14 (14.6)46 (47.9)82 (85.4)1.03 (0.48-2.19)0.93 (0.42-2.06)
GCA8 ( 8.7)59 (64.1)84 (91.3)1.80 (0.74-4.37)1.36 (0.46-4.05)
Negative family history2
ESCC16 (12.5)73 (57.0)112 (87.5)1.19 (0.65-2.18)1.18 (0.63-2.20)
GCA7 ( 7.3)54 (56.2)89 (92.7)1.19 (0.56-2.51)0.42 (0.16-1.04)
Positive family history3
ESCC8 (14.3)29 (51.8)48 (85.7)1.02 (0.46-2.29)0.95 (0.41-2.21)
GCA10 (16.1)38 (61.3)52 (83.9)0.95 (0.59-1.53)0.72 (0.31-1.70)
Table 3 Influence of the MMP-1 SNP on lymphatic metastasis in ESCC and GCA1.
GroupsLM negative cases (%)LM positive cases (%)aOR (95%CI)2
ESCC
1G/1G12 (16.7)6 (10.2)1.0 (ref.)
2G/2G31 (43.0)29 (49.2)1.72 (0.58-5.33)
1G/2G+2G/2G60 (83.3)53 (89.8)1.73 (0.60-4.97)
GCA
1G/1G7 (14.6)2 ( 4.4)1.0 (ref.)
2G/2G25 (52.1)28 (60.9)3.80 (0.71-20.41)
1G/2G+2G/2G41 (85.4)44 (95.6)3.66 (0.71-18.87)