Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 28, 2005; 11(16): 2385-2389
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2385
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2385
Groups | Control n (%) | ESCCn (%) | P1 | GCA n (%) | P1 |
Sex | |||||
Male | 229 (65.4) | 169 (72.2) | 0.08 | 134 (73.2) | 0.07 |
Female | 121 (34.6) | 65 (27.8) | 49 (26.8) | ||
Mean age | 51.7 (10.7) | 54.1 (10.2) | 0.061 | 55.0 (10.5) | 0.062 |
in yr (SD) | |||||
Smoking status3 | |||||
Ex-or current | |||||
smoker | 120 (42.9) | 96 (50.5) | 0.10 | 92 (55.4) | 0.015 |
Non-smoker | 160 (57.1) | 94 (49.5) | 74 (44.6) | ||
Family history of UGIC4 | |||||
Positive | 6 (4.7) | 56 (30.4) | <0.00016 | 62 (39.7) | <0.00016 |
Negative | 123 (95.3) | 128 (69.6) | 96 (60.3) | ||
MMP-1 SNP genotype | |||||
2G/2G | 194 (55.4) | 130 (55.6) | 0.611 | 12 (61.2) | 0.35 |
1G/2G | 105 (30.0) | 76 (32.5) | 51 (27.3) | ||
1G/1G | 51 (14.6) | 28 (11.9) | 20 (10.9) | ||
MMP-1 SNP allelotype | |||||
2G | 493 (70.4) | 336 (71.8) | 0.61 | 275(75.1) | 0.10 |
1G | 207 (29.6) | 132 (28.2) | 91 (24.9) |
1G/1G | 2G/2G | 2G/1G+2G/2G | aOR (95%CI)3 | aOR (95%CI)4 | |
Overall | |||||
Normal | 51 (14.9) | 194 (55.4) | 299 (85.4) | ||
ESCC | 28 (12.0) | 130 (55.6) | 206 (88.0) | 1.28 (0.78-2.09) | 1.23 (0.38-2.05) |
GCA | 20 (10.9) | 112 (61.2) | 163 (89.1) | 1.39 (0.80-2.41) | 1.34 (0.74-2.40) |
Non-smoker1 | |||||
Normal | 25 (15.6) | 89 (55.6) | 135 (84.4) | ||
ESCC | 10 (10.6) | 58 (61.7) | 84 (89.4) | 1.55 (0.65-3.46) | 1.54 (0.68-3.48) |
GCA | 10 (13.5) | 40 (54.1) | 64 (86.5) | 1.12 (0.49-2.58) | 1.20 (0.38-3.82) |
Smoker | |||||
Normal | 18 (15.0) | 64 (53.3) | 102 (85.0) | ||
ESCC | 14 (14.6) | 46 (47.9) | 82 (85.4) | 1.03 (0.48-2.19) | 0.93 (0.42-2.06) |
GCA | 8 ( 8.7) | 59 (64.1) | 84 (91.3) | 1.80 (0.74-4.37) | 1.36 (0.46-4.05) |
Negative family history2 | |||||
ESCC | 16 (12.5) | 73 (57.0) | 112 (87.5) | 1.19 (0.65-2.18) | 1.18 (0.63-2.20) |
GCA | 7 ( 7.3) | 54 (56.2) | 89 (92.7) | 1.19 (0.56-2.51) | 0.42 (0.16-1.04) |
Positive family history3 | |||||
ESCC | 8 (14.3) | 29 (51.8) | 48 (85.7) | 1.02 (0.46-2.29) | 0.95 (0.41-2.21) |
GCA | 10 (16.1) | 38 (61.3) | 52 (83.9) | 0.95 (0.59-1.53) | 0.72 (0.31-1.70) |
Groups | LM negative cases (%) | LM positive cases (%) | aOR (95%CI)2 |
ESCC | |||
1G/1G | 12 (16.7) | 6 (10.2) | 1.0 (ref.) |
2G/2G | 31 (43.0) | 29 (49.2) | 1.72 (0.58-5.33) |
1G/2G+2G/2G | 60 (83.3) | 53 (89.8) | 1.73 (0.60-4.97) |
GCA | |||
1G/1G | 7 (14.6) | 2 ( 4.4) | 1.0 (ref.) |
2G/2G | 25 (52.1) | 28 (60.9) | 3.80 (0.71-20.41) |
1G/2G+2G/2G | 41 (85.4) | 44 (95.6) | 3.66 (0.71-18.87) |
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Citation: Jin X, Kuang G, Wei LZ, Li Y, Wang R, Guo W, Wang N, Fang SM, Wen DG, Chen ZF, Zhang JH. No association of the
matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China. World J Gastroenterol 2005; 11(16): 2385-2389 - URL: https://www.wjgnet.com/1007-9327/full/v11/i16/2385.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i16.2385