Effects of ursodeoxycholic acid and/or low-calorie diet on steatohepatitis in rats with obesity and hyperlipidemia

Table 1 Changes of body weight and liver index.

Group	n	Body weight (g)	Liver index (%)
Control	9	351.1±43.0	2.957±0.301
NASH	10	423.5±65.2a	3.784±0.533b
UDCA	10	426.5±26.6	3.476±0.351
LCD	10	329.5±38.4d	3.199±0.552c
LCD+UDCA	15	310.3±38.6d	3.113±0.466c

^aP<0.05,

^bP<0.01 vs control,

^cP<0.05,

^dP<0.01 vs NASH group.

Table 2 Changes of major plasma lipid parameters.

Group	n	TG (mmol/L)	TCH (mmol/L)	FFA (mmol/L)
Control	9	0.63±0.22	1.27±0.17	429.2±96.7
NASH	10	0.62±0.10	1.60±0.41a	728.2±178.5b
UDCA	10	0.59±0.13	1.60±0.43	629.0±229.6
LCD	10	0.39±0.13d	2.04±0.50c	771.3±124.4
UDCA+LCD	15	0.51±0.17e	1.93±0.27c	605.6±152.2

^aP<0.05,

^bP<0.01 vs control,

^cP<0.05,

^dP<0.01 vs NASH group.

^eP<0.05 vs LCD group.

Table 3 Alterations of some biochemical variables in rat liver function.

Group	n	ALT (u/L)	AST (u/L)	A (g/L)	A/G
Control	9	40.2±7.1	98.7±24.8	25.13±4.61	0.71±0.11
NASH	10	75.3±40.21a	165.3±59.8b	27.40±2.04	0.73±0.08
UDCA	10	66.0±49.4	139.5±54.52	7.49±1.78	0.66±0.09
LCD	10	40.9±14.7c	140.4±32.3	24.51±4.69	0.71±0.16
UDCA+LCD	15	40.1±8.8c	111.8±22.9c	25.3±1.34	0.71±0.07

^aP<0.05,

^bP<0.01 vs control,

^cP<0.05 vs NASH group.

Table 4 Hepatic steatosis in groups of rats.

Group	n	-	+	++	+++
Control	9	9
NASH	10		3	6	1
UDCA	10	1	3	4	2
LCD	10	3	5	2
UDCA+LCD	15	8	1	4	2

Table 5 HAI in groups of rats.

Group	n	HAI
Control	9	0.8±0.8
NASH	10	3.4±2.1
UDCA	10	3.0±1.3
LCD	10	2.5±1.0
UDCA+LCD	15	1.9±1.1