Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat

Table 1 TUNEL-positive cells/field.

OBZVAD (n = 5)	OBZFA (n = 5)	SDMSO (n = 5)	SNS (n = 5)	OB (n = 5)
2.40±0.55	9.00±1.58	1.40±0.89	1.40±0.89	9.60±1.14

OBZVAD: obstructive jaundice with ZVAD. OBZFA: obstructive jaundice with ZFA. SDMSO: sham operation with DMSO. SNS: sham operation with normal saline. OB: obstructive jaundice. P = 0.008 (OBZVAD vs OBZFA). P = 0.008 (OBZVAD vs OB). P = 0.522 (OBZFA vs OB ). P = 1.000 (SDMSO vs SNS). P = 0.008 (SDMSO vs OB). P = 0.008 (SNS vs OB).

Table 2 Ductular proliferation (grade).

OBZVAD (n = 5)	OBZFA (n = 5)	SDMSO (n = 5)	SNS (n = 5)	OB (n = 5)
1.20±0.45	4.20±1.30	0.20±0.45	0.20±0.45	4.40±1.14

OBZVAD: obstructive jaundice with ZVAD. OBZFA: obstructive jaundice with ZFA. SDMSO: sham operation with DMSO. SNS: sham operation with normal saline. OB: obstructive jaundice. P = 0.007 (OBZVAD vs OBZFA). P = 0.007 (OBZVAD vs OB). P = 0.746 (OBZFA vs OB). P = 1.000 (SDMSO vs SNS). P = 0.007 (SDMSO vs OB). P = 0.007 (SNS vs OB).