Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 1 Manometric data before and after administration of GTN in 10 patients (mean±SD).

	Before GTN administration (control)	10 min after GTN administration	20 min after GTN administration
Sphincter of Oddi basal pressure (mmHg)	9.70±2.54	5.71±3.95a	5.80±3.42a
Amplitude of phasic contractions (mmHg)	88.84±68.77	52.07±23.59c	49.78±32.67c
Frequency of phasic contractions (n/min)	6.71±2.21	7.32±2.69	5.57±2.05
Common bile duct pressure (mmHg)	5.43±4.40	4.19±4.19	5.43±4.39

^aP<0.05,

^cP<0.05 vs themselves , n = 10 (n represent the number of patients involved in the research).

Table 2 Manometric data before and after administration of ISDN in 16 patients (mean±SD).

	Before ISDN administration (control)	10 min after ISDN administration	20 min after ISDN administration
Sphincter of Oddi basal pressure (mmHg)	10.78±10.79	5.56±3.38a	5.40±4.78
Amplitude of phasic contractions (mmHg)	92.06±43.36	60.82±33.64c	38.16±18.38d
Frequency of phasic contractions (n/min)	7.88±2.58	6.83±3.63	7.13±3.47
Common bile duct pressure (mmHg)	4.49±5.33	3.42±1.56	3.13±2.17

^aP<0.05,

^cP <0.05

^dP<0.01 vs themselves, n = 16 (n represents the number of patients involved in the research).

Table 3 Manometric data before and after administration of PTN in 11 patients (mean±SD).

	Before PTN administration (control)	10 min after PTN administration	20 min after PTN administration
Sphincter of Oddi basal pressure (mmHg)	10.95±7.49	8.59±11.90	5.92±4.04a
Amplitude of phasic contractions (mmHg)	86.19±42.04	68.08±38.23	59.51±27.35
Frequency of phasic contractions (n/min)	7.04±1.50	5.95±2.79	7.31±2.80
Common bile duct pressure (mmHg)	7.26±4.25	4.83±4.13	5.57±3.49

^aP<0.05 vs themselves, n = 11 (n represents the number of patients involved in the research).

Table 4 Manometric data before and after administration of morphine in 30 patients (mean±SD).

	Before morphine administration (control)	10 min after morphine administration
Sphincter of Oddi basal pressure (mmHg)	7.37±5.58	16.60±13.87b
Amplitude of phasic contractions (mmHg)	54.09±38.37	100.70±43.51d
Frequency of phasic contractions (n/min)	7.15±3.20	10.38±2.93f
Common bile duct pressure (mmHg)	3.75±1.95	10.49±8.21h

^bP<0.01,

^dP<0.01,

^fP<0.01,

^hP<0.01 vs themselves, n = 30 (n represents the number of patients involved in the research).

Table 5 Antagonism of GTN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after GTN associated administration associated	20 min after GTNadministration
Sphincter of Oddi basal pressure (mmHg)	12.49±5.40	6.46±6.88b	13.47±7.69
Amplitude of phasic contractions (mmHg)	96.56±48.49	56.54±27.19d	63.89±34.56
Frequency of phasic contractions (n/min)	8.98±1.34	6.96±1.83f	7.66±2.50
Common bile duct pressure (mmHg)	10.99±4.75	4.94±3.27h	7.87±4.72

^bP<0.01,

^dP<0.01,

^fP<0.01,

^hP<0.01 vs themselves, n = 10 (n represents the number of patients involved in the research).

Table 6 Antagonism of ISDN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after ISDN associated administration associated	20 min after ISDNadministration
Sphincter of Oddi basal pressure (mmHg)	24.63±19.55	5.43±4.82a	5.98±6.02b
Amplitude of phasic contractions (mmHg)	112.89±35.04	39.65±21.08d	43.45±28.65d
Frequency of phasic contractions (n/min)	11.46±3.83	8.82±2.67	8.52±2.21c
Common bile duct pressure (mmHg)	11.79±8.21	6.05±4.76e	5.75±3.87e

^aP<0.05,

^cP<0.05,

^eP<0.05,

^bP<0.01,

^dP<0.01 vs themselves, n = 10 (n represents the number of patients involved in the research).

Table 7 Antagonism of PTN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after PTN associated administration associated	20 min after PTN administration
Sphincter of Oddi basal pressure (mmHg)	13.25±9.63	10.61±11.00	13.12±12.09
Amplitude of phasic contractions (mmHg)	100.64±44.99	75.86±32.16a	66.17±35.88a
Frequency of phasic contractions (n/min)	10.70±2.76	9.95±1.08	9.04±1.71c
Common bile duct pressure (mmHg)	6.99±6.30	6.49±3.66	4.48±4.15

^aP<0.05,

^cP<0.05 vs themselves , n = 10 (n represents the number of patients involved in the research).