Impact of comorbid anxiety and depression on quality of life and cellular immunity changes in patients with digestive tract cancers

Table 1 Changes of HAMD and HAMA scores in different group.

Group	Case (%)	DSM-IV
	156	HAMD	HAMA
A	33 (21.15)	31.92±9.06b	21.75±7.96d
B	23 (14.74)	18.92±9.14	17.75±5.94d
C	35 (22.44)	25.92±8.17b	11.92±6.10
D	65 (41.67)	16.33±6.25	8.19±3.70
F		39. 78	35.25
P		0.00	0

^bP<0.01 vs group D;

^dP<0.01 vs group D.

Table 2 Comparison of social support, coping style and cellular immunity in group A, B and C with group D.

Item	Standard scores				P
	A	B	C	D	P1	P2	P3
Social support	43.14	42.25	44.00	44.30	0.62	0.82	0.86
Subjective support	25.00	26.00	25.17	23.50	0.50	0.35	0.48
Objective support	11.50	12.25	12.00	12.00	0.54	0.90	1
Utilization of supportac	6.16	5.75	6.83	7.80	0.04	0.03	0.37
Active coping	20.71	20.25	19.5	21.60	0.62	0.53	0.37
Passive coping	11.43	9.75	7.17	9.10	0.12	0.72	0.76
Lymphocytea(%)	32.87	29.20	37.20	34.00	0.01	0.33	0.39
Granulocyte (%)	62.70	68.30	58.75	56.90	0.11	0.19	0.81
Monocyte (%)	4.07	2.50	4.14	6.08	0.49	0.18	0.33
CD3f (%)	52.00	52.60	42.50	59.57	0.21	0.25	0.00
CD4d (%)	25.10	37.30	22.85	25.55	0.88	0.00	0.24
CD8de (%)	31.30	19.30	34.10	38.12	0.24	0.00	0.03
CD56a (%)	26.02	23.20	30.65	32.20	0.02	0.11	0.42

^aP<0.05 vs group D;

^cP<0.05,

^dP<0.01 vs group D;

^eP<0.05,

^fP<0.01 vs group D.

Table 3 Analysis of QOL in patients with digestive tract cancer.

	Standard scores				P
	A	B	C	D	P1	P2	P3
Global QL	41.67	56.67	35.00	66.67	0.20	0.71	0.12
Function
PFa	61.43	68.33	69.33	74.67	0.04	0.52	0.12
RFa	67.62	70.83	70.00	76.67	0.02	0.44	0.15
EF	75.00	47.92	93.33	90.00	0.11	0.24	0.25
CF	66.67	50.00	73.33	86.67	0.36	0.69	0.16
SF	47.62	54.17	63.33	56.67	0.79	0.50	0.65
Symptom
FA	50.79	16.67	24.44	25.56	0.10	0.17	0.12
NV	21.43	33.33	10.00	20.00	0.57	0.56	0.93
PA	25.67	29.17	23.03	16.67	0.43	0.26	0.52
Single item
DY	23.33	16.67	23.00	6.00	0.10	0.12	0.10
SLbc	41.00	36.00	18.33	13.33	0.00	0.04	0.36
AP	61.00	41.67	33.33	23.33	0.40	0.23	0.05
COad	55.67	16.67	50.00	10.00	0.04	0.76	0.00
DI	22.33	16.67	15.32	12.15	0.05	0.17	0.14
FI	83.33	66.67	41.67	46.67	0.29	0.55	0.26

^aP<0.05,

^bP<0.01 vs group D;

^cP<0.05 vs group D;

^dP <0.01 vs group D.

Table 4 Pearson correlation analysis among multiple variables in group A.

Variable	QL	Social support	Depression	Anxiety	Active coping	Passive coping
QL	1.00	0.18	0.28	0.07	0.42a	0.02
Social support	0.18	1.00	0.06	0.13	0.17	0.05
Depression	0.28	0.06	1.00	0.31	0.07	0.15
Anxiety	0.07	0.13	0.31	1.00	0.29	0.05
Active coping	0.42a	0.17	0.07	0.29	1.00	0.28
Passive coping	0.02	0.05	0.15	0.05	0.28	1.00
Age (yr)	0.10	0.28	0.09	0.02	0.001	0.12
Lymphocyte	0.08	0.07	0.66a	0.21	0.36	0.37
Granulocyte	0.22	0.18	0.08	0.06	0.44	0.39
Monocyte	0.41	0.35	0.14	0.28	0.37	0.23
CD3	0.18	0.15	0.32	0.17	0.09	0.34
CD4	0.04	0.22	0.07	0.31	0.24	0.03
CD8	0.18	0.03	0.21	0.05	0.08	0.06
CD56	0.67a	0.24	0.36	0.19	0.43	0.82b

^aP<0.05,

^bP<0.01.

Table 5 Multivariate analysis of contributing factors of QOL with step-wise regression in patients with digestive tract cancer.

Model	Unstandardized coefficients (B)	Standardized coefficients (β)	t	P
Utilization of support	1.05	1.32	3 245.61	0.000
CD56	0.16	0.69	2 860.22	0.001
Active coping	0.79	0.77	1 288.73	0.011
FA	0.16	0.13	148.03	0.010
SL	0.04	0.02	144.74	0.014
Depression	0.001	0.005	16.67	0.038