Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic rats

Table 1 Hemodynamic values in sham-operated (sham) and common bile duct-ligated (CBL) rats.

	Sham (n = 6)	CBL (n = 8)
Cardiac index (mL·min/100 g body wt)	29.4±0.6	46.7±0.7a
Mean arterial pressure (mmHg)	107±5	97±10
Systemic vascular resistance	289±9	167±7a
(dyn·s/cm5×103/100 g body wt)
Heart rate (beats/min)	315±6	327±10
Portal pressure (mmHg)	7.9±1.3	19.8±0.6a

Values are mean±SE.

^aP<0.05 vs sham rats.

Table 2 Contractile response of different agents to the endothelial-denuded aortic rings from sham and CBL rats.

Vasopressor	Parameter	Sham	CBL
PEP	pEC50	6.41±0.1	6.53±0.8
	Rmax (g) (10-5 mol/L)	3.29±0.37	1.99±0.21a
AVP	pEC50	6.51±0.2	7.08±0.9
	Rmax (g) (10-5 mol/L)	3.45±0.28	2.31±0.49a
U-46619	pEC50	7.43±0.13	7.81±0.26
	Rmax (g) (10-6 mol/L)	3.18±0.27	3.19±0.17
NaF/AlCl3	pEC50	0.83±0.43	1.01±0.01
	Rmax (g) (1 mol/L)	3.68±0.13	3.42±0.25
PdBU	pEC50	7.05±0.4	7.05±0.7
	Rmax (g) (10-6 mol/L)	3.87±0.14	3.92±0.22

Values are mean±SE; sham: sham-operated rats; CBL: common bile duct-ligation rats, PEP: phenylephrine, n = 10, in each group with different agonist stimulation,

^aP<0.05 vs sham rats.