Ornithine decarboxylase gene is overexpressed in colorectal carcinoma

Table 1 Immunohistochemical assay of ODC protein in colorectal carcinoma.

Histological grade and Duck’s stage	-	+	++	+++	Total	Positive rate (%)	Pb
Normal	18	1	0	0	19	5
Grade 1 well differentiated	1	2	4	9	16	93.75	<0.01
Grade 2 moderately differentiated	0	0	7	21	28	100	<0.01
Grade 3 poorly differentiated	0	0	8	7	15	100	<0.01
Grade 4 undifferentiated	0	1	6	3	10	100	<0.01
Duck’S A/B	1	1	11	17	31	96.7	<0.01
Duck’s C/D	0	1	14	23	38	100	<0.01

^bP<0.01 vs normal tissue.

Table 2 ODC mRNA expression in normal and colorectal tumor tissues.

Samples	ODC mRNA expression (n)			Total (n)	P
	Low	Over	high
Normal	31	0	0	31	<0.01
Tumor	0	19	12	31
Gender
Male	0	9	6	15	>0.05
Female	0	10	6	16
Histologic grade
Well-to-moderately	0	18	9	27	>0.05
differentiated
Undifferentiated	0	1	3	4
Duck’s stage
A/B	0	17	5	22	<0.05
C/D	0	2	7	9