Expression of p16 gene and Rb protein in gastric carcinoma and their clinicopathological significance

Table 1 P16 protein expression, p16 gene mutation and deletion in GC.

Histologic types	n	P16 protein					p16 gene
		-	+	++	+++	Positive rate (%)	Mutation	Deletion
Normal gastric mucosaa	80	3	41	20	16	96	0/25	0/25
Dysplastic gastric mucosaa	50	5	12	19	14	92	0/25	0/25
GC	122	64	13	20	25	48	0/25	5/25

^aP<0.05 vs GC.

Table 2 P16 protein expression in various histologic types of GC.

Histologic types	n	Positive	Negative rate (%)	Positive
Well-differentiated adenocarcinomaa	29	11	18	38
Poorly-differentiated adenocarcinomaa	41	21	20	51
Undifferentiated carcinomaa	26	15	11	58
Signet ring cell carcinomaa	16	10	6	62
Mucoid carcinoma	10	1	9	10

^aP<0.05 vs mucoid carcinoma.

Table 3 P16 protein expression in primary GC and lymph node metasatic GC.

Types	n	Positive	Positive rate (%)
Primary GCa	30	14	47
Lymph node metasatic GC	30	5	17

^aP<0.05 vs lymph node metasatic GC.

Table 4 Rb protein expression in GC.

Types	n	Negative		Positive		Positive rate (%)
		-	+	++	+++
Normal gastric mucosaa	80	1	10	20	49	99
Dysplastic gastric mucosaa	50	10	8	17	15	80
GC	122	49	17	30	26	60

^aP<0.05 vs GC.

Table 5 Correlation between expression of P16 and Rb proteins in GC.

	n	Positive Rb		Negative Rb
		n	(%)	n	(%)
Positive P16a	44	14	16	30	33
Negative P16	46	39	43	7	8

^aP<0.05 vs negative P16.