Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV

Table 1 Baseline characteristics in 270 patients (mean±SD).

Variable factors	All patients (n = 270)	Recurrent patients (n = 136)	Recurrent patients (n = 136)
			Early phase (n = 107)	Late phase (n = 29)
Age (yr)	46.9±13.0	4.0±11.5	44.2±11.1	47.7±12.9
Sex (male/female)	247/23	126/10	Aug-99	27/2
Gross tumorclassification (small/solitary/nodular)	66/168/36	35/77/24	23/63/21	12/14/3
Edmondson classification (I-II/III-IV)	128/142	65/71	46/61	19/10
Tumor capsule (present/absent)	55/215	23/113	13/94	10/19
Vascular invasion (present/absent)	145/125	79/57	62/45	7/12
Alpha-fetoprotein (positive/negative)	141/129	85/51	75/32	10/19
Hepatocirrhosis (positive/negative)	200/70	105/31	82/25	23/6
Type of liver resection (non-anatomical/anatomical)	149/121	78/58	59/48	19/10
Incisal margin ( ≤1 cm/>1 cm)	22/258	15/131	14/93	1/28
HBV infection (positive/negative)	239/31	128/8	102/5	26/3
Blood transfusion (yes/no)	199/71	100/36	75/32	25/4
Survival time (d)	–	575.9±499.6	384.7±313.1	1248.5±450.9
Recurrent time (d)	–	435.6±417.9	23.1±199.6	1072.2±396.9

Note: Small HCC (SHCC), solitary large HCC (SLHCC), nodular HCC (NHCC).

Table 2 Multiple regression analysis of recurrence and metastasis of 136 HCC patients.

Variable	Results on early phase			Results on late phase
	Regression coefficient	t	P	Regression coefficient	t	P
AFP level	-0.328	-3.693	0.000	-0.280	-1.306	0.208
Hepatocirrhosis	0.024	0.274	0.785	-0.377	-1.530	0.143
Type of liver resection	0.023	0.260	0.795	0.245	1.235	0.233
Incisal margin	0.217	2.485	0.015	0.106	0.420	0.679
Blood transfusion	-0.223	2.553	0.012	0.268	1.266	0.222
Gross tumor classification	-0.051	-0.583	0.561	-0.518	-2.433	0.026
Vascular invasion	0.266	3.013	0.003	-0.361	-1.562	0.136
Tumor capsule	0.023	0.259	0.797	-0.281	-1.111	0.281
Edmondson classification	0.126	1.444	0.152	0.065	0.292	0.774

Note: Dependent variable was the time of recurrence and metastasis (d).

Table 3 Statistics of the HBV infective pattern.

Serum markers	All patients (n = 270)		Recurrent patients (n = 136)
	Positive number	Ratio (%)	Positive number	Ratio (%)
HBsAg+HBeAg+HBcAb+	20	7.4	14	10.3
HBsAg+HBeAb+HBcAb+	118	43.7	62	45.6
HBsAg+HBcAb+	57	21.1	32	23.5
HBsAb+	9	3.3	6	4.4
HBcAb+	2	0.7	2	1.5
HBeAb+HBcAb+	7	2.6	1	0.7
HBsAg+	16	5.9	9	6.6
HBsAb+HBeAb+HBcAb+	2	0.7	0	0.0
HBsAg+HBeAb+	6	2.2	1	0.7
HBsAb+HBeAb+	2	0.7	1	0.7
HBV negative	31	11.5	8	5.9

Table 4 Compare the HBV infective pattern between SLHCC and NHCC.

Serum markers	All patients (n = 270)		Recurrent patients (n = 136)		χ2	P
	SLHCC ratio (%)	NHCC ratio (%)	SLHCC ratio (%)	NHCC ratio (%)
HBsAg+HBeAg+HBcAb+	40.0	13.3	33.3	25.0	4.244	0.039
HBsAg+HBeAb+HBcAb+	56.3	12.5	53.1	12.2	0.003	0.955
HBsAg+HBcAb+	70.2	12.8	73.1	11.5	0.079	0.778
HBsAb+	71.4	14.3	60.0	20.0	1.833	0.176
HBeAb+HBcAb+	75.0	12.5	0.0	100.0	4.876	0.000
HBsAg+	63.2	5.3	50.0	12.5	4.867	0.027
HBV negative	69.6	4.3	87.5	0.0	4.877	0.027