Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats

doi:10.3748/wjg.v11.i13.1951

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Apr 7, 2005 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2005; 11(13): 1951-1956
Published online Apr 7, 2005. doi: 10.3748/wjg.v11.i13.1951

Table 1 Scores for necro-inflammation (focal necrosis, confluent necrosis, piecemeal necrosis, focal and portal inflammation, and apoptosis) and fibrosis of groups using modified HIA grading system (mean±SE).

	Scores for necro-inflammation	Scores for fibrosis
SO	0.25±0.16	0±0
BDL	11.87±0.83^a	1.37±0.18^a
BDL+vehicle	11.12±1.00^a	1.35±0.20^a
BDL+melatonin	6.87±0.63^c	0.75±0.25^c

SO: sham operation; BDL: bile duct ligation; HAI: Histological Activity Index.

^aP<0.05 vs SO.

^cP<0.05 vs BDL, BDL+vehicle.

Table 2 Number of biliary canals in five portal sites for each specimen (mean±SE).

	Number of biliary canals
SO	9.37±0.49
BDL	40.37±2.50^a
BDL+vehicle	39.50±2.67^a
BDL+melatonin	39.87±2.01^a

SO: sham operation; BDL: bile duct ligation.

^aP<0.05 vs SO.

Table 3 MDA, GSH and NO_X concentrations measured in hepatic tissue.

	MDA (µmol/g tissue)	GSH (µmol/g tissue)	NO_X (nmol/g tissue)
SO	147.47±6.69	0.88±0.03	180.70±6.58
BDL	200.14±21.30^a	0.65±0.02^a	400.46±48.89^a
BDL+vehicle	211.12±19.98	0.63±0.04^a	411.66±77.32
BDL+melatonin	115.93±6.80^c	0.74±0.02^e	290.38±32.32^e

SO: sham operation; BDL: bile duct ligation; MDA: malondialdehyde; GSH: reduced glutathione; NO_X: NO₂ (nitrite)+NO₃ (nitrate).

^aP <0.05 vs SO.

^cP<0.05 vs BDL, BDL+vehicle.

^eP<0.05 vs BDL.

Citation: Esrefoglu M, Gül M, Emre MH, Polat A, Selimoglu MA. Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. World J Gastroenterol 2005; 11(13): 1951-1956
URL: https://www.wjgnet.com/1007-9327/full/v11/i13/1951.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i13.1951