Cell proliferation, apoptosis and the related regulators p27, p53 expression in hepatocellular carcinoma

Table 1 Clinicopathological characteristics of 47 patients.

Clinicopathological parameters	Number	%
Gross type
Massive	21	44.7
Nodular	26	55.3
Tumor size
≤5 cm	19	40.4
>5 cm	28	59.6
Cellular differention
I+ II	39	82.9
III+IV	8	17.1
Stage
I+ II	13	27.7
III+IV	34	72.3
Capsular infiltration
Present	19	40.4
Absent	28	59.6
Extrahepatic metastasis
Present	15	31.9
Absent	32	68.1

Table 2 Relationship between PI, AI and clinicopathological features.

Parameters	AI (%)	P	PI (%)	P
Gross type
Massive	8.29±2.26	0.376	30.10±3.81	0.739
Nodular	8.88±2.30		30.54±4.99
Tumor size
≤5 cm	8.11±2.03	0.208	29.79±4.85	0.492
>5 cm	8.96±2.41		30.71±4.23
Cellular differentiation
Well or moderate	8.87±2.38	0.091	30.46±4.46	0.686
Poor	7.38±1.19		29.75±4.74
Stage
I + II	7.46±2.30	0.030a	28.85±3.85	0.306
III+IV	9.06±2.15		30.91±4.60
Capsular infiltration
Present	8.79±2.68	0.674	31.79±4.10	0.066
Absent	8.50±2.01		29.36±4.50
Extrahepatic metastasis
Present	9.00±1.89	0.436	32.53±3.93	0.019a
Absent	8.44±2.45		29.31±4.38

^aP<0.05 vs Stage III+IV.

Table 3 Relationship among p27, cytoplasmic p27 and p53 staining with clinicopathological features.

Parameters	p27		P	p53		P	Cytoplasmic p27 LI (%)	P
	+	–		+	–
Gross type
Massive	8	13	0.77	10	11	0.237	26.85±21.61	0.349
Nodular	11	15		8	18		17.11±14.62
Tumor size
≤5 cm	11	8	0.044a	7	12	0.866	25.48±24.52	0.068
>5 cm	8	20		11	7		19.93±15.71
Cellular differentiation
Well or moderate	16	5	0.855	13	26	0.126	20.13±16.34	0.688
Poor	3	23		5	3		22.91±22.08
Stage
I + II	7	6	0.246	6	7	0.498	29.24±23.59	0.021a
III+IV	12	22		12	22		15.58±10.46
Capsular infiltration
Present	4	15	0.026a	6	13	0.435	18.13±14.52	0.276
Absent	15	13		12	16		24.12±20.87
Extrahepatic metastasis
Present	4	11	0.188	5	10	0.632	14.73±9.15	0.141
Absent	15	17		13	19		23.82±20.39

^aP<0.05 vs HCC.

Table 4 Relationship among p27, cytoplasmic p27 and p53 staining with PI and AI.

		AI	P	PI	P
p53	(+)	8.61±2.87	0.989	29.50±4.93	0.314
	(–)	8.62±1.88		30.86±4.16
p27	(+)	8.42±1.84	0.633	29.26±4.81	0.176
	(–)	8.75±2.56		31.07±4.15
Cytoplasmic p27
High		7.16±1.90	0.044a	30.33±5.17	0.708
Low		8.42±2.44		29.81±4.37

^aP<0.05 vs cytoplasmic p27 low.

Table 5 Relationship between coexpression of p27 and p53 staining with PI and AI.

	p53 (–) p27 (+)	p53 (+) p27 (–)	p53 (+) p27 (+)	p53 (–) p27 (–)
PI	27.50±5.61	31.93±4.17	30.43±4.39	30.13±3.94
AI	7.85±2.43	8.23±2.31	7.48±1.36	7.05±2.17

Table 6 Correlation between the expression of p27, p53 and clinicopathological factors.

Parameters	p53-p27+	p53+p27-	p53+p27+	p53-p27-	P
Gross type
Massive	4	6	4	7	0.546
Nodular	8	5	3	10
Tumor size
≤5 cm	6	2	5	6	0.359
>5 cm	6	8	2	12
Cellular differentiation
Well or moderate	11	8	5	15	0.119
Poor	1	3	2	2
Stage
I + II	5	2	3	3	0.127
III+IV	7	8	4	15
Capsular infiltration
Present	4	5	1	9	0.999
Absent	8	6	6	8
Extrahepatic metastasis
Present	3	3	2	7	0.22
Absent	9	8	5	10