Study on hepatoprotective effect of peptide S-8300 from shark liver

Table 1 Effect of S-8300 on the sGPT, sGOT and LDH in mice injected with CCl₄.

Group	Dosage (mg/kg)	sGPT (U/dL)	sGOT (U/dL)	LDH (U/dL)
Normal control	–	13.4±2.5b	42.4±10.9b	150.3±45.8b
Model control	–	135.9±6.5	238.8±8.7	240.4±6.0
HGF	3	96.1±12.6b	163.8±14.2b	175±52.8b
S-8300	0.3	98.2±12.5b	142.1±31.5b	196.1±59.6b
	1	78.7±10.7b	102.0±14.0b	173.1±52.4b
	3	52.2±11.0b	67.5±6.9b	155.1±46.8b

^bP<0.01 vs model control.

Table 2 Effect of S-8300 on the GSH, SOD and MDA in mice injected with CCl₄.

Group	Dosage (mg/kg)	GSH (µg/mg prot)	SOD (U/mg prot)	MDA (nmol/mg prot)	General protein (mg/mL)
Normal control	–	27.75±0.86b	26.10±0.81b	0.55±0.025b	21.22±0.39
Model control	–	14.93±0.45	19.05±0.73	1.06±0.040	21.13±0.35
HGF	3	19.02±0.42b	21.82±0.82b	0.89±0.038b	21.28±0.49
S-8300	0.3	17.40±0.10b	21.19±0.69b	0.91±0.035b	21.3±0.29
	1	20.01±0.74b	23.39±0.42b	0.81±0.026b	21.11±0.44
	3	24.17±0.91b	24.51±1.01b	0.64±0.027b	21.3±0.43

^bP<0.01 vs model control.

Table 3 Effect of S-8300 on the levels of serum hemolysin and IL-2 in mice treated with Cy.

Group	Dosage (mg/kg)	IL-2(pg/mL)	Serum hemolysin (A540)
Normal control	–	12.72±1.62b	0.101±0.007b
Model control	–	5.81±0.87	0.063±0.006
S-8300	0.3	7.44±078b	0.082±0.003b
	1	8.19±0.95b	0.084±0.004b
	3	9.74±1.16b	0.094±0.005b

^bP<0.01 vs model control.