Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma

Table 1 Expression of paxillin protein categorized by pathological variables.

Variables	Paxillin		P
	-	+
Serum AFP level
≤25 ng/mL (n = 22)	13	9	0.604
>25 ng/mL (n = 29)	15	14
HBsAg
Positive (n = 16)	8	8	0.638
Negative (n = 35)	20	15
Microsatellite nodule
Absent (n = 31)	17	14	0.991
Present (n = 20)	11	9
Tumor size
≤3 cm (n = 18)	8	10	0.272
>3 cm (n = 33)	20	13
Cirrhosis
Absent (n = 36)	20	16	0.886
Present (n = 15)	8	7
Necrosis
Absent (n = 24)	13	11	0.922
Present (n = 27)	15	12
Portal vein thrombosis
Absent (n = 37)	24	13	0.021
Present (n = 14)	4	10
Differentiation
Well (n = 35)	24	11	0.004
Low (n = 16)	4	12
Extra-hepatic metastasis
Absent (n = 41)	26	15	0.014
Present (n = 10)	2	8

Table 2 Expression of syndecan-1 protein categorized by pathological variables.

Variables	Syndecan-1		P
	-	+
Serum AFP level
≤25 ng/mL (n = 22)	8	14	0.28
>25 ng/mL (n = 29)	15	14
HBsAg
Positive (n = 16)	6	10	0.465
Negative (n = 35)	17	18
Microsatellite nodule
Absent (n = 31)	13	18	0.578
Present (n = 20)	10	10
Tumor size
≤3 cm (n = 18)	9	9	0.607
>3 cm (n = 33)	14	19
Cirrhosis
Absent (n = 36)	17	19	0.64
Present (n = 15)	6	9
Necrosis
Absent (n = 24)	10	14	0.646
Present (n = 27)	13	14
Portal vein thrombosis
Absent (n = 37)	15	22	0.292
Present (n = 14)	8	6
Differentiation
Well (n = 35)	10	25	0.001
Low (n = 16)	13	3
Extra-hepatic metastasis
Absent (n = 41)	15	26	0.014
Present (n = 10)	8	2

Table 3 Expression of EMMPRIN protein categorized by pathological variables.

Variables	EMMPRIN		P
	-	+
Serum AFP level
≤25 ng/mL (n = 22)	12	10	0.242
>25 ng/mL (n = 29)	11	18
HBsAg
Positive (n = 16)	9	7	0.284
Negative (n = 35)	14	21
Microsatellite nodule
Absent (n = 31)	13	18	0.576
Present (n = 20)	10	10
Tumor size
≤3 cm (n = 18)	9	9	0.607
>3 cm (n = 33)	14	19
Cirrhosis
Absent (n = 36)	18	18	0.281
Present (n = 15)	5	10
Necrosis
Absent (n = 24)	11	13	0.992
Present (n = 27)	12	15
Portal vein thrombosis
Absent (n = 37)	15	22	0.292
Present (n = 14)	8	6
Differentiation
Well (n = 35)	16	19	0.897
Low (n = 16)	7	9
Extra-hepatic metastasis
Absent (n = 41)	19	22	0.721
Present (n = 10)	4	6

Table 4 Association between paxillin and syndecan-1 protein.

Paxillin	Syndecan-1		P
	-	+
Negative	8	20	0.01
Positive	15	8

Table 5 Association between EMMPRIN and paxillin, syndecan-1 protein.

Paxillin	EMMPRIN		P
	-	+
Negative	15	13	0.184
Positive	8	15
Syndecan-1
Negative	13	10	0.141
Positive	10	18