Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth

Table 1 Relative cell numbers in different cell-cycle phases after treatment with sirolimus, tacrolimus and the combination of both. The doses used in these experiments were 25 ng/mL for each compound. Results of one representative experiment are shown.

Cell cycle	Sub-G1	G1	S	G2/M
Hep 3B
Control	6	69	10	14
Sir	6	73	10	10
Tac	4	65	17	13
Sir + Tac	16	63	10	9
SK-Hep 1
Control	1	61	16	22
Sir	2	69	12	16
Tac	2	54	13	20
Sir + Tac	2	82	8	7