Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma

Table 1 Effect of genistein on cell cycle progression of SGC-7901 cells (%).

Genistein(mg/mL)	24 h			48 h
	G0/G1	S	G2/M	G0/G1	S	G2/M
0	57.9	32.52	9.57	64.13	29.75	6.12
5	50.64b	30.05	19.31b	56.16b	29.41	14.43b
10	43.01b,d	30.18a	27.80b,d	49.85b,d	30.01	20.14b,d
20	36.96b,d,f	30.66a	32.38b,d,f	39.26b,d,f	36.88b,d,f	23.86b,d,f

^bP<0.01, vs genistein 0.0 μg/mL, ^dP<0.01, vs genistein 10.0 μg/mL, ^fP<0.01, vs genistein 5.0 μg/mL, ^aP<0.05, vs genistein 0.0 μg/mL.

Table 2 Expression of cyclin B₁ and cyclin D₁ in SGC-7901 cells treated with genistein.

Genistein (mg/mL)	Positive rate (%, 24 h)		Positive rate (%, 48 h)
	cyclin B1	cylinD1	cyclin B1	cylinD1
0	36.8	91.9	48.2	88.1
5	46.5b	70.5b	54.8b	54.3b
10	53.4b,d	49.3b,d	62.8b,d	43.9b,d
20	72.3b,d,f	25.4b,d,f	85.2b,d,f	22.1b,d,f

^bP<0.01, vs genistein 0.0 μg/mL, ^dP<0.01, vs genistein 5.0 μg/mL, ^fP<0.01, vs genistein 10.0 μg/mL.