Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA

Table 1 Relationship between iNOS expression and pathological parameter in gastric cancer tissues.

Parameter	Cases n	iNOS expression		Positive rate(%)	P
		Positive	Negative
Morphological type
Polypoid or fungating type	30	22	8	73.3
Ulcerative type	34	27	7	79.4	>0.05
Infiltrating type	21	16	5	76.2
Histological classification
Adenocarcinoma	31	23	8	74.2
Scirrhous carcinoma	15	12	3	80
Medullary carcinoma	17	13	4	76.5	>0.05
Mucoid carcinoma	22	16	6	72.7
Degree of differentiation
Poorly differentiated	35	30	5	85.7a	<0.05
Well differentiated	51	33	17	64.7
Clinical stage
Early gastric carcinoma	36	24	12	66.7
Advanced gastric carcinoma	49	44	5	89.8c	<0.05
Lymph node metastasis
Positive	51	44	7	86.3e	<0.05
Negative	34	19	15	55.6

^aP<0.05 vs the group of well-differentiated carcinomas; ^cP<0.05 vs the group of early gastric carcinomas; ^eP<0.05 vs the expression rate of iNOS in cases having no lymph node metastasis.

Table 2 Relationship between the expressions of iNOS and p53, PCNA in gastric cancer.

	Cases n	iNOS expression		Positive rate(%)
		Positive	Negative
P53
Positive	72	59	13	81.9a
Negative	13	5	7	38.5
PCNA
Positive	69	56	13	81.2c
Negative	16	6	10	37.5

^aP<0.05, A comparison of iNOS expression between p53-positive and p53-negative groups; ^cP<0.05, A comparison of iNOS expression between PCNA-positive and PCNA-negative groups.