Peroxisome proliferator activated receptor-γ in pathogenesis of experimental fatty liver disease

Table 1 Biochemical features of rats with fatty liver disease

Group	n1	ALT (U/L)	TNFα (μg/L)	MDA (μmol/g)
A	1 0	34 ± 9.02	1.36 ± 0.35	5.71 ± 0.25
B	9	119 ± 17.15a	3.39 ± 0.42a	7.26 ± 0.32a
C	10	103 ± 17.24a	3.02 ± 0.37a	6.72 ± 0.31a
D	9	125 ± 16.51a	5.01 ± 0.52abd	9.12 ± 0.42abd

¹One rat died in groups B, D respectively in the process of experiment..

^aP < 0.05 vs the normal control;

^bP < 0.01 vs the alcohol group;

^dP < 0.01 vs the fat-rich diet group.

Table 2 Quantitative evaluation of liver histology of rats (%)

Groups	n	Steatosis	Inflammation and necrosis	Collagen
A	10	1.34 ± 0.33	0.67 ± 0.66	2.03 ± 0.87
B	9	12.79 ± 2.73a	4.35 ± 0.56a	11.85 ± 3.89a
C	10	35.82 ± 8.52ab	3.05 ± 0.72a	7.90 ± 2.79ab
D	9	37.97 ± 11.48ab	5.71 ± 1.03ac	19.02 ± 4.01abc

^aP < 0.01 vs the normal control;

^bP < 0.05 vs the alcohol group;

^cP < 0.05 vs the fat-rich diet group.

Table 3 Level of PPARγ protein and mRNA in rat livers (%)

Group	n	PPARγ protein	PPARγ mRNA
A	1 0	18.34 ± 3.73	0.8097 ± 0.098
B	9	8.82 ± 2.52a	0.2530 ± 0.072a
C	1 0	11.73 ± 2.51a	0.3647 ± 0.084a
D	9	3.43 ± 1.48abd	0.1226 ± 0.054abd

^aP < 0.05 vs the normal control;

^bP < 0.01 vs the alcohol group;

^dP < 0.01 vs the fat-rich diet group.

Table 4 Correlation between levels of PPARγ protein and biochemical, histological parameters in model rats (r value)

Groups	ALT	TNFα	MDA	Steatosis	Inflammation	Fibrosis
B	-0.263	-0.745b	-0.560 a	-0.437	-0.568b	-0.728a
C	-0.493	-0.662a	-0.772b	-0.323	-0.671a	-0.812b
D	-0.352	-0.624b	-0.781b	-0.329	-0.891b	-0.679b

^aP < 0.05 vs the normal control;

^bP < 0.01 vs the alcohol group.