GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Table 1 GSTT1 and GSTM1 genotype frequencies among gastric cancer (GC) and chronic gastritis (CG) patients and controls (C)

Groups	n	GSTT1 Null (%)	GSTM1 Null (%)	GSTT1/GSTM1
				+/+ (%)	+/0 (%)	0/+ (%)	0/0 (%)
GC	100	17 (17.0)	47 (47.0)	43 (43.0)	40 (40.0)	10 (10.0)	7 (7.0)
CG	100	12 (12.0)	38 (38.0)	57 (57.0)	31 (31.0)	5 (5.0)	7 (7.0)
C	150	28 (18.6)	62 (41.3)	64 (42.7)	58 (38.7)	24 (16.0)	4 (2.6)

+/+: Presence of GSTT1 and GSTM1; +/0: Presence of GSTT1 and absence of GSTM1; 0/+: Absence of GSTT1 and presence of GSTM1; 0/0: Absence of GSTT1 and GSTM1.

Table 2 Associations of GSTT1 and GSTM1 genotypes with demographic risk factors in gastric cancer (GC) and chronic gastritis (CG) cases and controls (C) n (%)

Groups	Categories	Genotype
		GSTM1 positive	GSTM1 null	GSTT1 positive	GSTT1 null
C	Ethnicity
	Caucasian	75 (55.6)	60 (44.4)	114 (84.4)	21 (15.6)
	Negroid	13 (86.7)	2 (13.3)	8 (53.3)	7 (46.7)
		P = 0.020		P = 0.003
GC	Ethnicity
	Caucasian	42 (46.3)	45 (51.7)	73 (83.9)	14 (16.1)
	Negroid	11 (84.6)	2 (15.4)	10 (76.9)	3 (23.1)
		P = 0.017		P = 0.690
CG	H pylori
	Infection
	No	43 (71.7)	17 (28.3)	54 (90.0)	6 (10.0)
	Yes	19 (48.7)	20 (51.3)	34 (87.2)	5 (12.8)
		P = 0.032		P = 0.748

Table 3 CYP2E1 genotype frequencies among gastric cancer and chronic gastritis patients and controls n (%)

Groups	Genotype
	c1/c1	c1/c2
GC	89 (89.0)	11 (11.0)
CG	91 (91.0)	9 (9.0)
C	134 (89.3)	16 (10.7)

c1/c1=homozygote for the common allele, c1/c2=heterozygote. GC: Gastric cancer; CG: Chronic gastritis; C: Control.