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©The Author(s) 2004.
World J Gastroenterol. Apr 15, 2004; 10(8): 1103-1109
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1103
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1103
Table 1 Musshoff’s modified Ann-Arbor stage
Stage | Definition |
Ie | Involvement of a single extralymphatic organ or site1 |
Ie1 | Involvement of mucosa or submucosa |
Ie2 | Involvement of more than submucosa |
IIe | Involvement of two or more lymph node regions on the same side of the diaphragm |
with localized involvement of an extralymphatic organ and site1,2 | |
IIe1 | Involvement of regional lymph nodes |
IIe2 | Involvement of other lymph nodes beyond regional area |
IIIe | Localized involvement of a single extralymphatic organ or site with involvement of lymph node regions on |
both sides of the diaphragm (IIIe) or involvement of the spleen (IIIs) or both (IIIe+s)1,2 | |
IVe | Involvement of extranodal site(s) beyond that designated as “e” more than one extranodal |
deposit at any location, any involvement of liver or bone marrow1,2 | |
E | localized, solitary involvement of extralymphatic tissue, excluding liver and bone marrow |
1 | Direct spread of a lymphoma into adjacent tissues or organs does not influence stage. Multifocal involvement of a single extralymphatic organ is classified as stage IE and not stage IV. Involvement of two or more segments of the gastrointestinal tract, isolated and not in continuity, is classified as stage IV (disseminated involvement of one or more extralymphatic organs). |
2 | The definitions of regional lymph nodes for individual sites of extranodal lymphomas are identical to the definitions of regional lymph nodes for individual sites of gastrointestinal carcinomas. For example, the regional lymph nodes for a primary gastric lymphoma are the perigastric nodes along the lesser and greater curvatures and the nodes located along the left gastric, common hepatic, splenic, and celiac arteries. |
Table 2 Age and sex distribution of patients
LG group | HG group | Total | P-value | |
n (%) | 201 (35.1) | 37 (64.9) | 57 | |
Age (±SD) | 52.6 (±11.4) | 57.7 (±13.9) | 55.9 (±13.2) | n.s. |
Sex | 10:10 | 20:17 | 30:27 | n.s. |
(M:F) | (1:1) | (1.18:1) | (1.11:1) |
Table 3 Presenting symptoms and duration
Symptom | n (%) |
Epigastric pain, discomfort | 39 (68.4) |
Gastrointestinal bleeding | 9 (15.8) |
Weight loss | 9 (15.8) |
Indigestion | 7 (12.3) |
Nausea/vomiting | 4 (7.0) |
Anorexia | 4 (7.0) |
Diarrhea | 2 (3.5) |
Others | 3 (5.3) |
No Symptom | 6 (10.5) |
Histopathology | Duration of symptom |
LG group | 11.9 ± 24.9 |
HG group | 5.2 ± 9.0 |
Total | 7.6 ± 16.7 mo |
P = n.s. |
Table 4 Preoperative endoscopic findings and diagnosis accuracy
LG group (%) | HG group (%) | Total (%) | |
Lymphoma | 6 (37.5) | 10 (33.3) | 16 (34.8) |
AGC | 4 (25.0) | 17 (56.7) | 21 (45.7) |
EGC | 5 (31.3) | 2 (6.7) | 7 (15.2) |
Benign ulcer | 1 (6.3) | 1 (3.3) | 2 (4.3) |
Total | 16 (100) | 30 (100) | 46 (100) |
Dx. Rate | Lymphoma/total (%) | ||
Primary Dx | 6/16 (37.5) | 10/30 (33.3) | 16/46 (34.8) |
D/Dx | 8/16 (50.0) | 15/30 (50.0) | 23/46 (50.0) |
Table 5 Comparison between gastroscopic biopsy and post-operative histopathology
Postop. | LG group (%) | HG group (%) | Total (%) |
Preop. | |||
LG group | 15 (78.9) | 4 (21.1) | 19 (100.0) |
HG group | 2 (7.4) | 25 (92.6) | 8 (100.0) |
Total | 17 | 29 | 46 |
Table 6 Operation methods
LG group (%) | HG group (%) | Total (%) | |
Subtotal gastrectomy | 10 (50.0) | 21 (56.8) | 30 (52.6) |
Other partial gastrectomy | 2 (10.0) | 3 (8.1) | 5 (8.8) |
Total gastrectomy | 8 (40.0) | 14 (37.8) | 22 (38.6) |
TG | 7 (35.0) | 8 (21.6) | 15 (26.3) |
TG + splenectomy | 1 (5.0) | 6 (16.2) | 7 (12.3) |
Total | 20 (100) | 37 (100) | 57 (100) |
Table 7 Location of lesions
LG group (%) | HG group (%) | Total (%) | |
Lower 1/3 | 7 (35.0) | 19 (51.4) | 26 (45.6) |
Middle 1/3 | 8 (40.0) | 10 (27.0) | 18 (31.6) |
Upper 1/3 | 3 (15.0) | 5 (13.5) | 8 (14.0) |
Lower + middle | 2 (10.0) | 2 (5.4) | 4 (7.0) |
Lower + upper | 0 (0.0) | 1 (2.7) | 1 (1.8) |
Total | 20 (100) | 37 (100) | 57 (100) |
Table 8 TNM stage
Stage | LG group (%) | HG group (%) | Total (%) |
Ia (+ no residual) | 15 (78.9) | 7 (18.9) | 22 (39.3) |
Ib | 3 (15.8) | 12 (32.4) | 15 (26.8) |
II | 0 (0.0) | 11 (29.7) | 11 (19.6) |
IIIa | 0 (0.0) | 6 (16.2) | 6 (10.7) |
IV | 1 (5.3) | 1 (2.7) | 2 (3.6) |
Total | 191 (100) | 37 (100) | 56 (100) |
Table 9 Musshoff stage
Stage | LG group (%) | HG group (%) | Total (%) |
Ie1 (+ no residual) | 15 (78.9) | 7 (18.9) | 22 (39.3) |
Ie2 | 2 (10.5) | 15 (40.5) | 17 (30.4) |
IIe1 | 1 (5.3) | 14 (37.8) | 15 (26.8) |
IIe2 | 1 (5.3) | 1 (2.7) | 2 (3.6) |
Total | 191 (100) | 37 (100) | 56 (100) |
Table 10 Number of lesions
Number | LG group (%) | HG group (%) | Total (%) |
None or single | 17 (85.0) | 29 (83.3) | 46 (80.7) |
0 | 1 (5.0) | 1 (2.7) | 2 (3.5) |
1 | 16 (80.0) | 28 (75.7) | 44 (77.2) |
Multiple | 3 (15.0) | 8 (21.6) | 11 (19.3) |
2 | 1 (5.0) | 7 (18.9) | 8 (14.0) |
6 | 0 (0.0) | 1 (2.7) | 1 (1.8) |
Diffuse | 2 (10.0) | 0 (0.0) | 2 (3.5) |
Total | 20 (100) | 37 (100) | 57 (100) |
Table 11 Characteristics of patients whose disease recurred
Sex/age | Op. | Loc. | Size(cm) | N | T | LN | Musshoff stage | Site of recurrence | DFS (mo) | Survival | OS (mo) |
F/80 | ST | LB | 6x3 | 1 | PM | 8/26 | IIe2 | abdominal LN | 0.4 | Dead1 | 10.1 |
M/34 | T | MB | 8x2.5 | 1 | PM | 12/21 | IIe1 | abdominal LN, | 6.6 | Dead | 9.1 |
bone marrow | |||||||||||
M/34 | ST | MB | 2.2x3 | 1 | SS | 0/60 | Ie2 | remnant stomach | 7.6 | Alive | 57.2 |
F/59 | ST | LB | 4x3.5 | 1 | SM | 0/19 | Ie1 | paraaortic LN | 10.4 | Alive | 13.4 |
M/85 | ST | MB & LB | 4x3 | 2 | PM | 0/64 | Ie2 | chest | 18.2 | Dead2 | 42.0 |
F/55 | T | HB | 13x10 | 1 | colon, | 0/11 | Ie2 | abdominal LN | 26.3 | Dead | 37.4 |
pancreas | |||||||||||
M/67 | ST | LB | 10x8 | 1 | SS | 16/53 | IIe1 | cervical LN | 26.8 | Dead3 | 31.6 |
M/70 | ST | MB | 3x2 | 2 | SM | 5/19 | IIe1 | unknown3 | 70.4 | Dead | 70.6 |
1.5x0.8 |
- Citation: Kong SH, Kim MA, Park DJ, Lee HJ, Lee HS, Kim CW, Yang HK, Heo DS, Lee KU, Choe KJ. Clinicopathologic features of surgically resected primary gastric lymphoma. World J Gastroenterol 2004; 10(8): 1103-1109
- URL: https://www.wjgnet.com/1007-9327/full/v10/i8/1103.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i8.1103