Effect of SEN virus coinfection on outcome of lamivudine therapy in patients with hepatitis B

Table 1 Association of SENV with severity of liver disease

	Normal ALT (n)	Abnormal ALT (n)	Total
SENV DNA P	4	1	5
SENV DNA N	32	8	40

Abbreviations: P, positive; N, negative.

Table 2 Association of SENV with HBeAg response to lamivudine treatment

	HBeAg P (n)	HBeAg N (n)	Total
SENV-DNA P	5	0	5
SENV-DNA N	36	4	40

Abbreviations: P, positive; N, negative.

Table 3 Effect of lamivudine treatment on patients with SENV coinfection

	HBV DNApositivepatients (n)	Mean Log10HBV DNA(copies/mL)	HBV DNAnegativepatients(n)
SENV DNA Positive	4	5.50 ± 0.47	1
SENV DNA Negative	10	4.98 ± 0.75	30

Abbreviations: P, positive; N, negative.

Table 4 Clinical features of 5 patients with SENV infection

Patient	Sex(M/F)	Age(yr)	ALT(IU/L)	HBeAg	HBVDNA	YMDDmotif
SENV-D1	M	24	25	P	P	YMDD
SENV-D2	M	34	96	P	P	YIDD
SENV-H1	M	27	38	P	P	YMDD
SENV-H2	M	29	17	P	N
SENV-H3	M	19	29	P	P	YVDD

Abbreviations: P, positive; N, negative; M, male.