Xu D, Tian DY, Zhang ZG, Chen HY, Song PH. Effect of SEN virus coinfection on outcome of lamivudine therapy in patients with hepatitis B. World J Gastroenterol 2004; 10(7): 968-971 [PMID: 15052676 DOI: 10.3748/wjg.v10.i7.968]
Corresponding Author of This Article
Dr. De-Ying Tian, Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095, Wuhan 430030, Hubei Province, China. xudongtj@tom.com
Article-Type of This Article
Viral Hepatitis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 1, 2004; 10(7): 968-971 Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.968
Table 1 Association of SENV with severity of liver disease
Normal ALT (n)
Abnormal ALT (n)
Total
SENV DNA P
4
1
5
SENV DNA N
32
8
40
Table 2 Association of SENV with HBeAg response to lamivudine treatment
HBeAg P (n)
HBeAg N (n)
Total
SENV-DNA P
5
0
5
SENV-DNA N
36
4
40
Table 3 Effect of lamivudine treatment on patients with SENV coinfection
HBV DNApositivepatients (n)
Mean Log10HBV DNA(copies/mL)
HBV DNAnegativepatients(n)
SENV DNA Positive
4
5.50 ± 0.47
1
SENV DNA Negative
10
4.98 ± 0.75
30
Table 4 Clinical features of 5 patients with SENV infection
Patient
Sex(M/F)
Age(yr)
ALT(IU/L)
HBeAg
HBVDNA
YMDDmotif
SENV-D1
M
24
25
P
P
YMDD
SENV-D2
M
34
96
P
P
YIDD
SENV-H1
M
27
38
P
P
YMDD
SENV-H2
M
29
17
P
N
SENV-H3
M
19
29
P
P
YVDD
Citation: Xu D, Tian DY, Zhang ZG, Chen HY, Song PH. Effect of SEN virus coinfection on outcome of lamivudine therapy in patients with hepatitis B. World J Gastroenterol 2004; 10(7): 968-971