Antineoplastic effects of octreotide on human gallbladder cancer cells in vitro

Table 1 The inhibitory effect of octreotide on colony forming ability of GBC-SD (mean ± SD,%)

Octreotide (nmol/L)	Colony forming rate
0	82.62 ± 7.63
1	70.51 ± 1.88a
10	68.96 ± 4.88b
100	51.41 ± 18.50b
1000	27.48 ± 2.68d

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs the control group (n = 3).

Table 2 Effects of octreotide on the cell cycle kinetics and apoptosis of GBC-SD cells (mean ± SD,%)

Group	Apoptosis	G0/G1	S	G2/M
Control	0.49 ± 0.21	57.47 ± 6.69	32.40 ± 4.86	10.13 ± 5.99
Octreotide 1000 nmol/L	22.05 ± 8.09a	71.08 ± 4.58a	22.72 ± 6.68	6.20 ± 2.84

^aP < 0.05 vs the control group (n = 4).

Table 3 Effects of octreotide on the p53 and bcl-2 expression of GBC-SD cells (mean ± SD,%)

Group	Percentage of P53 protein positive	Percentage of Bcl-2 protein positive
Control	50.09 ± 4.64	87.12 ± 7.40
Octreotide 1000 nmol/L	44.12 ± 5.30a	80.46 ± 5.45a

^aP < 0.05 vs the control group (n = 10).