Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

doi:10.3748/wjg.v10.i7.1032

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Apr 1, 2004 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 1, 2004; 10(7): 1032-1036
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.1032

Table 1 Effect of BPC 157 on indomethacin induced gastric ulcer formation (n = 10)

Administration	Agents	Dosage (ng/kg)	Ulcer (mm²)	Inhibition ratio(%)
im	Saline control		19.22 ± 2.95
	Excipient control		20.90 ± 7.55
	Famotidine	40 000	8.20 ± 4.68	60.8^b
	BPC 157	200	9.71 ± 5.00	53.5^b
	BPC 157	400	7.22 ± 4.01	65.5^b
	BPC 157	800	7.22 ± 4.64	65.5^b
ig	Saline control		20.18 ± 8.50
	Famotidine	40 000	8.28 ± 3.45	58.9^b
	BPC 157	200	13.56 ± 6.79	32.8
	BPC 157	400	9.92 ± 2.62	50.8^b
	BPC 157	800	9.75 ± 5.25	51.7^b

^bP < 0.01 vs excipient control or saline control.

Table 2 Effect of BPC 157 on pylorus ligation induced gastric ulcer formation (n = 10)

Administration	Agents	Dosage (ng/kg)	Ulcer (mm²)	Inhibition ratio(%)
im	Saline control		131.2 ± 58.1
	Excipient control		130.2 ± 68.2
	Famotidine	40 000	55.7 ± 46.7	57.2^b
	BPC 157	200	80.9 ± 22.8	37.8^b
	BPC 157	400	47.6 ± 27.8	63.5^b
	BPC 157	800	44.8 ± 19.4	65.6^b
ig	Saline control		140.1 ± 78.1
	Famotidine	40 000	34.1 ± 33.1	75.7^b
	BPC 157	200	110.5 ± 41.5	21.1
	BPC 157	400	64.1 ± 35.4	54.2^a
	BPC 157	800	58.6 ± 37.6	58.2^b

^aP < 0.05,

^bP < 0.01 vs excipient control (im) or saline control (ig).

Table 3 Effect of BPC 157 on acetate induced gastric ulcer area (n = 10)

Administration	Agents	Dosage (ng/kg)	Ulcer (mm²)	Inhibition ratio(%)
im	Saline control		13.66 ± 4.10
	Excipient control		13.98 ± 4.00
	Famotidine	40 000	9.18 ± 3.04	34.3^a
	BPC 157	200	9.75 ± 3.62	30.2^a
	BPC 157	400	6.81 ± 3.67	51.3^b
	BPC 157	800	5.60 ± 1.91	59.9^b
ig	Saline control		14.96 ± 6.21
	Famotidine	40 000	3.20 ± 1.54	78.6^b
	BPC 157	200	9.78 ± 4.28	34.6^a
	BPC 157	400	8.13 ± 2.84	45.7^b
	BPC 157	800	7.80 ± 2.83	47.8^b

^aP < 0.05,

^bP < 0.01 vs excipient control (im) or saline control (ig).

Table 4 Effects of BPC 157 on rebuilding of glandular epithe-lium and formation of granulation tissue in acetate induced chronic gastric ulcer (n = 10)

Administration	Agent	Dosage (ng/kg)	Diameter of remnant ulcer (μm)	Thickness of granulation tissue (μm)
im	Saline control		3 928 ± 636	718 ± 165
	Excipient control		3 981 ± 594	652 ± 169
	Famotidine	40 000	3 175 ± 577^b	768 ± 268
	BPC 157	200	3 266 ± 671^a	992 ± 295^b
	BPC 157	400	2 658 ± 744^b	1 018 ± 202^b
	BPC 157	800	2 426 ± 511^b	1 012 ± 306^b
ig	Saline control		4 098 ± 795	673 ± 112
	Famotidine	40 000	1 772 ± 458^b	805 ± 100^a
	BPC 157	200	3 260 ± 728^a	797 ± 110^a
	BPC 157	400	2 972 ± 564^b	837 ± 114^b
	BPC 157	800	2 904 ± 577^b	862 ± 171^b

^aP < 0.05,

^bP < 0.01 vs excipient control (im) or saline control (ig).

Citation: Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, Bao CJ, Yan Z, Zhang YQ. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol 2004; 10(7): 1032-1036
URL: https://www.wjgnet.com/1007-9327/full/v10/i7/1032.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i7.1032