Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients

Table 1 Spectra of APC mutations in carcinomas from HNPCC patients

Tumor ID	APC nt change	Codon	Target sequence
Point mutations
T27	C > T	332	CpG
T533	C > T	1 338	CpG
K1, C × 7*	C > T	1 450	CpG
Frameshift mutations
C × 7*	1 bp ins	847	TCTCaAAAAAGAT
C086*	1 bp ins	941	TCGGaAAAATTCA
K40	1 bp ins	1 454	CCTaAAAAATAAA
22	1 bp ins	1 554	GCAGaAAAAAACTAT
C x 10	1 bp ins	1 935	TTTCCCCaAGTCA
K10	1 bp del	907	TCTgGGTCT
C086*	1 bp del	1 464	AAGAGAGagAGTGG
K39	1 bp del	799	GATtaTGTT
T10	1 bp del	1 416	AGTGGcATTATA

Note: ID means tumor identification; nt stands for neocleotide; ‘>’ for transition or transvertion; each tumor with more than 2 mutations marked by *; del for deletion; ins for insertion; small letter for nucleotide frameshift.