Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis

Table 1 Relationship between expression of VEGF-C and CCR7 and clinicopathologic parameters in patients with gastric carcinoma

	No. of patients	Expression of VEGF-C		P value	Expression of CCR7		P value
		Positive	Negative		Positive	Negative
Age				NS*			NS
<61 years	46	21	25		23	23
≥61years	72	41	31		40	32
Gender				NS			NS
Male	71	38	33		39	32
Female	47	24	23		24	23
Tumor size				NS			<0.01
<5 cm	53	23	30		21	32
≥5 cm	65	39	26		42	23
Tumor location				NS			NS
Lower third (L)	81	40	41		44	37
Middle third (M)	21	12	9		11	10
Upper third (U)	16	10	6		8	8
Lauren classification				NS			NS
Intestinal	53	24	29		25	28
Diffuse	53	30	23		32	21
Mixed	12	8	4		6	6
Depth of invasion				NS			<0.001
T1/2	24	9	15		5	19
T3/4	94	53	41		58	36
Lymph node metastasis				<0.001			<0.001
Positive	61	45	16		50	11
Negative	57	17	40		13	44
Lymphatic invasion				<0.001			<0.001
Positive	68	48	20		51	17
Negative	50	14	36		12	38
Vascular invasion				<0.01			NS
Positive	35	25	10		20	15
Negative	83	37	46		43	40
Stage				<0.001			<0.001
I, II	55	19	36		13	42
III, IV	63	43	20		50	13

*NS, not significant.

Table 2 Correlation between expression of VEGF-C and CCR7 and lymph node metastasis determined by MSCT and pathological examination

	No. of patients	Expression of VEGF-C		P value	Expression of CCR7		P value
		Positive	Negative		Positive	Negative
Lymph node metastasis1				NS3			<0.05
Positive	21	12	9		14	7
Negative	18	6	12		5	13
Lymph node metastasis2				<0.01			<0.01
Positive	19	13	6		14	5
Negative	20	5	15		5	15

¹Lymph node metastasis determined by MSCT;

²Lymph node metastasis determined by pathological examination;

³NS, not significant.

Table 3 Comparison of MSCT and pathological diagnosis of N stage

Pathologic N stage	No. of patients	N stage determined by MSCT
		N0	N1	N2
N0	20	151	2	3
N1	10	2	51	3
N2	9	1	1	71

¹MSCT findings were concordant with pathological findings

Table 4 Relationship between expression of VEGF-C and CCR7 after the subdivision and lymph node metastasis

Lymph node metastasis	No. of patients	Expression of VEGF-C and CCR7
		CCR7(+) andVEGF-C(+)	CCR7(+) andVEGF-C(-)	CCR7(+) andVEGF-C(+)	CCR7(+) andVEGF-C(-)
Positive	61	41	9	4	7
Negative	57	7	6	10	34