Salvage therapy for hepatocellular carcinoma with thalidomide

Table 1 Description of cases

Age (yr)
Median	58 ± 14.1
Range	21-86
Sex
Male	81
Female	18
Modality of diagnosis
Cytological/histological	33
Imaging + AFP > 400 ng/mL	30
Imaging + AFP < 400 ng/mL or unknown	36
Cirrhosis
Absent	5
Present	80
Chronic parenchymalds’	14
Causes of liver disease
Hepatitis B	58
Hepatitis C	22
Hepatitis B + C	5
Non B and Non C	6
Alcoholic	1
Child-Pugh stage (unknown = 2)
A	43
B	33
C	21
AFP (ng/mL) (unknown = 10)
10 <	17
11-400	33
400	39
Portal vein thrombosis (unknown = 3)
No	46
Yes	50
Pre ThalidomideTreatment (unknown = 7)
No	30
Yes	72
Surgery	11
PEI	16
TACE	49
Radiation	6
Chemotherpay	3

Table 2 Okuda staging for HCC

Point	0	1
Size of tumor	< 50% of liver	> 50 %
Ascites	No	Yes
Albumin	≥ 3	< 3
Bilirubin	< 3	≥ 3
Stage I: 0	II: 1 or 2	III: 3 or 4

Table 3 CLIP scoring system

Scores Variables	0	1	2
Child-pugh stage	A	B	C
Tumor morphology	Unninodular	Multinodular	Massive
	and extension	and extension	or extension
	≤ 50%	≤ 50%	> 50%
AFP	< 400	≥ 400
Portal vein thrombosis	No	Yes

Table 4 Hepatocellular carcinoma stage and survival time, Okuda stage and survival time

Group		Stage			MSD
		I	II	III
A (n = 19)	Case No.	5	9	5
	Survival days	161	26.8	10.5	25.2
B (n = 76)	Case No.	19	41	16
	Survival days	171.5	136.5	47.3	108.5

MSD: medium survival day.

Table 5 Hepatocellular carcinoma stage and survival time, CLIP classification and survival time

Group		Score
		0	1	2	3	4	5	6
A (n = 20)	Case	0	2	2	2	8	5	1
	Survival days		220.5	49	42	35	12.3	11
B (n = 76)	Case	1	8	20	20	15	9	3
	Survival days	> 345	301	150.5	106.8	96.2	59.5	19.3

Table 6 Response rate of hepatoma treated with thalidomide

	Tumor response		Stabilization rate
	N	CR/PR	SD	PD	(PR + SD)
Patt et al[6]	21	0/1	11	9	12 (57%)
Chen et al[8]	42	0/2	15	25	17 (43%)
Kong et al[5]	11	0/1	4	6	5 (45%)
Lin et al[4]	27	0/1	1	25	2 (8%)
Schwartz et al[7]	20	1/1	7	11	9 (45%)
Total	121	1/6	38	76	45 (37%)
Wang et al	99	0/6	Survival 16 upto Apr 31 ’03

CR: complete response, PR: partial response, SD: stable disease, PD: Progressive disease.