Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer

Table 1 Maspin expression in normal mucosa, dysplasia, and primary cancer of the stomach

Groups	n	Maspin expression
		-	+~+++	%
Normal mucosa	182	37	145	79.8b
Dysplasia	69	17	52	75.4d
Primary cancer	113	56	57	50.4

Compared with primary cancer

^bP = 0.000 (Χ² = 27.589, Pearson’r = 0.306),

^dP = 0.000 (Χ² = 11.075, Pearson’r = 0.247).

Table 2 Relationship between maspin expression and clinico-pathological features of gastric cancer

Clinicopathological features	n	Maspin expression
		-	+	++	+++	%	rs	P value
Tumor size							0.000	0.999
< 4 cm	47	22	13	7	5	53.2
≥ 4 cm	66	34	11	15	6	48.5
Borrmann’s classification							0.014	0.896
I, II	28	12	9	5	2	57.1
III, IV	59	30	10	13	6	49.2
Invasive depth							0.280	0.03
Above submucosa	26	10	4	6	6	61.5
Muscularis propria	34	12	11	7	4	64.7
Below subserosa	53	34	9	9	1	35.8
Metastasis							0.208	0.027
-	75	31	18	19	7	58.7
+	38	25	6	3	4	34.2
TNM staging							0.004	0.967
O, I	46	22	11	10	3	52.2
II, III, IV	67	34	13	12	8	49.3
Growth pattern							0.032	0.767
Mass	23	13	4	5	1	43.5
Nest	30	11	6	8	5	63.63
Diffuse	34	18	9	5	2	47.1
Lauren’s classification							0.228	0.015
Intestinal	36	12	8	11	5	66.7
Diffuse	57	33	12	8	4	42.1
Mixed	20	11	4	3	2	45.0
Nakamura’s classification							0.212	0.024
Differentiated	53	20	14	12	7	62.3
Undifferentiated	60	30	10	1	4	10.0
Caspase-3 expression							0.246	0.09
-	78	44	17	12	5	56.4
+~+++	35	12	7	10	6	65.7

Table 3 Relationship between maspin expression and MVD in primary gastric cancer

Maspin expression	n	MVD (mean ± SD)	F value	P value
-	56	51.72 ± 26.87	4.911	0.029
+~+++	57	41.70 ± 20.92
Total	113	46.67 ± 24.47