Expression of pituitary tumor transforming gene in human gastric carcinoma

Table 1 Histological types of gastric adenocarcinomas and immunohistochemical PTTG1 staining (75 cases) n%

	n	-	+	++	P value
Total carcinomas	75	26(34.7)	31(41.3)	18(24.0)
Papillary adenocarcinomas	4	1(25.0)	2(50.0)	1(25.0)
Tubular adenocarcinomas
Well differentiated	18	6(33.3)	6(33.3)	6(33.3)
Moderately differentiated	22	7(31.8)	7(31.8)	8(36.4)
Poorly differentiated adenocarcinomas
Solid types	7	4(40.0)	2(28.6)	1(14.3)
Nonsolid type	10	4(40.0)	6(60.0)	0(0.0)
Signet-ring cell carcinoma	12	4(33.3)	7(58.3)	1(8.3)
Mucinous adenocarcinoma	2	2(100.0)	0(0.0)	0(0.0)	> 0.05

See Materials and Methods for classification of staining intensity.

Table 2 Invasive grades of gastric adenocarcinomas and PTTG1 immunohistochemistry (75 cases) n%

	n	-	+	++	P value
m	17	6(35.3)	5(29.4)	6(35.3)
sm	21	5(23.8)	11(52.4)	5(23.8)
mp	12	5(41.7)	4(33.3)	3(25.0)
ss	6	2(33.3)	4(66.7)	0(0.0)
se	19	8(42.1)	7(36.8)	4(21.1)	>0.05
Total	75	26(34.7)	31(41.3)	18(24.0)

m, mucosal carcinomas; sm, submucosal infiltrative carcinomas; mp, carcinomas invading the proprial muscle layers; ss, carcinomas reaching the subserosa; se, carcinomas penetrating the serosal surface.

Table 3 PTTG1 expression in primary adenocarcinomas and metastatic lymph nodes (19 cases) n(%)

	n	-	+	++	P value
Primary adenocarcinomas	19	12(63.2)	7(36.8)	0(0.0)
Metastatic lymph nodes	19	4(21.0)	9(47.2)	6(31.6)	< 0.005