Evaluation of high-resolution computed tomography and pulmonary function tests in patients with chronic hepatitis C virus infection

Table 1 Knodell histological activity index (KHAI) and pul-monary function tests (mean ± SD) in patients with chronic hepatitis C virus infection and controls

Features	Patients with	Controls	P
	HCV (n = 34)	(n = 10)
KHAI	9.0 ± 4.7	-	-
VCa	86.3 ± 10.9	83.6 ± 7.9	NS
FVCa	85.8 ± 12.0	80.6 ± 8.3	NS
FEV1a	86.5 ± 11.0	82.3 ± 6.7	NS
FEF25-75a	78.2 ± 18.8	81.7 ± 13.5	NS
DLCOa	66.3 ± 21.3	80.7 ± 15.3	NS
DLCO/VAa	77.7 ± 18.0	85.2 ± 14.5	NS

^a: % predicted; NS: Not significant.

Table 2 High-resolution computed tomography (HRCT) findings in patients with chronic hepatitis C virus infection and controls

	Patients with HCV infection			Controls
HRCT Findings	n	%	HRCT scores	n	%	HRCT scores
Ground-glass attenuation	1	2.9	2	0	0	-
Nodular areas of high attenuation	6	17.6	3.6 ± 1.5	0	0	-
Consolidation	0	0	-	0	0	-
Non-septal lines	5	14.7	2.7 ± 1.7	0	0	-
Septal lines	4	11.7	3.9 ± 1.6	0	0	-
Honeycombing	0	0	-	0	0	-
Distortion	0	0	-	1	10	2

P = 0.03, χ² = 4.7.

Table 3 Multiple linear regression analysis of Knodell histological activity index (KHAI) and age and sex in patients with chronic hepatitis C virus infection

	Independent variables
	Whole regression equation			Age			Sex
Dependent variable	R2	F	p	β	t	p	β	t	p
KHAI	0.61	38.8	< 0.001	0.78	6.2	< 0.001	a	a	a

a: Not significant, R²: squared multiple correlation coefficient, F: F value, β: Partial correlation coefficients, t: t value of regression coefficients.

Table 4 Multiple linear regression analysis of high-resolution computed tomography (HRCT) score, pulmonary function test, Kn odell histological activity index (KHAI), age, sex and smoking in patients with chronic hepatitis C virus infection

	Independent variables
Dependent	Whole regression equation			KHAI			Age			Sex			Smoking
variables	R2	F	p	β	t	p	β	t	p	β	t	p	β	t	p
HRCT score	0.17	5.4	0.028	a	a	a	0.42	2.3	0.028	a	a	a	a	a	a
VC	0.19	6.1	0.020	a	a	a	-0.44	-2.5	0.020	a	a	a	a	a	a
FVC	0.24	8.0	0.009	a	a	a	-0.49	-2.8	0.009	a	a	a	a	a	a
FEV1	0.25	8.6	0.007	a	a	a	-0.50	-2.9	0.007	a	a	a	a	a	a
FEF25-75	0.30	11.1	0.003	a	a	a	-0.55	-3.3	0.003	a	a	a	a	a	a
DLCO	0.16	4.9	0.036	a	a	a	-0.40	-2.1	0.036	a	a	a	a	a	a
DLCO/VA	0.22	3.5	0.047	0.55	2.2	0.04	-0.66	-2.6	0.015	a	a	a	a	a	a

a: Not significant, R²: squared multiple correlation coefficient, F: F value, β: Partial correlation coefficients, t: t value of regression coefficients.