Brief Reports
Copyright ©The Author(s) 2004.
World J Gastroenterol. Dec 15, 2004; 10(24): 3639-3642
Published online Dec 15, 2004. doi: 10.3748/wjg.v10.i24.3639
Table 1 Levels of MCP-1, sICAM-1, sP-selectin, IL-6 and IL-10 in patients with chronic hepatitis C during IFN + RBV therapy in responders (R) and non-responders (NR)
0-wk16-wk32-wk48-wkControl
sICAM-1 (pg/mL)NR434 ± 104ab372 ± 111ab404 ± 87b389 ± 77b230 ± 29
R527 ± 109ab433 ± 87ab353 ± 98b363 ± 99
sP-selectin (pg/mL)NR240 ± 101ab137 ± 47145 ± 33147 ± 41144 ± 75
R144 ± 57a131 ± 68131 ± 5823 ± 47
MCP-1 (pg/mL)NR290 ± 91365 ± 124ab315 ± 61325 ± 50a268 ± 109
R281 ± 84285 ± 55a335 ± 32b286 ± 59a
IL10 (pg/mL)NR0.45 ± 0.46a0.81 ± 0.540.77 ± 0.680.9 ± 0.630.62 ± 0.83
R0.88 ± 0.78a0.89 ± 0.740.69 ± 0.731.01 ± 0.77
IL6 (pg/mL)NR0.65 ± 0.61ab2.21 ± 0.94ab1.07 ± 1.68b1.56 ± 1.32b0.22 ± 0.49
R0.16 ± 0.37ab0.76 ± 0.69ab0.77 ± 0.55b1.05 ± 1.21b
ALT (IU/mL)NR82 ± 4026 ± 1723 ± 1061 ± 9132 ± 6
R60 ± 3021 ± 624 ± 622 ± 6
Prothrombin index (%)NR96 ± 2397 ± 698 ± 1199 ± 1098 ± 6
R5 ± 790 ± 1083 ± 1390 ± 7
Blood platelet (G/L)NR196 ± 21189 ± 45190 ± 52179 ± 51203 ± 45
R196 ± 21189 ± 45190 ± 5217 ± 51
Table 2 Correlation of adhesion molecules, cytokines and MCP-1 levels with liver histopathology in responders (R) and non-responders (NR)
Grading (inflammation)
Periportal
Intralobular
Staging (fibrosis)
RNRRNRRNR
sICAM-1rN0.360.380.56N0.32
PN< 0.05< 0.05< 0.01N< 0.05
MCP-1r0.35NNNNN
P< 0.05NNNNN
IL-6rNN0.53NN0.38
PNN< 0.01NN< 0.05
IL-10rNNNNNN
PNNNNNN
sP-selectinrNNNNNN
PNNNNNN