Guan J, Chen XP, Zhu H, Luo SF, Cao B, Ding L. Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line. World J Gastroenterol 2004; 10(23): 3522-3527 [PMID: 15526378 DOI: 10.3748/wjg.v10.i23.3522]
Corresponding Author of This Article
Xiao-Ping Chen, M.D., Professor and Chairman, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. chenxp_53@163.com
Article-Type of This Article
Brief Reports
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 3 Changes of MDR related genes after treated with U0126 (mean ± SD)
Group
MDR-1
MRP-1
LRP
Transfected
0.15 ± 0.03
0.62 ± 0.11
0.78 ± 0.13
Treated with U0126
0.08 ± 0.02
0.37 ± 0.09
0.44 ± 0.09
P
0.028
0.040
0.020
Table 4 Changes of MDR related proteins after treated with U0126 (mean ± SD)
Group
MDR-1
MRP-1
LRP
Transfected
0.22 ± 0.04
0.17 ± 0.02
0.14 ± 0.02
Treated with U0126
0.13 ± 0.04
0.12 ± 0.02
0.09 ± 0.02
P
0.04
0.038
0.04
Citation: Guan J, Chen XP, Zhu H, Luo SF, Cao B, Ding L. Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line. World J Gastroenterol 2004; 10(23): 3522-3527