Effects of endostatin on expression of vascular endothelial growth factor and its receptors and neovascularization in colonic carcinoma implanted in nude mice

Table 1 Reduction in tumor mass and MVD after endostatin treatment (mean ± SD)

	Control	Endostatin	F	P
Mass	1.198 ± 0.105	0.197 ± 0.049	22.56	aP = 0.0005
MVD	100.143 ± 4.290	31.857 ± 3.515	151.62	bP = 0.0001

^aP = Mass difference between Control group and Endostatin group,

^bP = MVD difference between Control group and Endostatin group.

Table 2 Expression of VEGF and VEGFR2/Flk-1 in tumor after Endostatin treatment

	Positive	Negative		χ2	P
Control-VEGF (1)	65	5	(1) vs (2)	0.119	0.730
Endostatin-VEGF (2)	66	4
Control-Flk-1 (3)	64	6	(3) vs (4)	13.745	aP = 0.001
Endostatin- Flk-1 (4)	46	24

^aP = Flk-1 difference between Control group and Endostatin group.