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©The Author(s) 2004.
World J Gastroenterol. Nov 15, 2004; 10(22): 3240-3244
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3240
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3240
Table 1 Cyclin B1 expression status of 34 gastric cancer tissues with or without MAD2 overexpression
| Cyclin B1 level | ||
| T > N | T = N | |
| MAD2 level | ||
| T > N (n = 25) | 16 | 9 |
| T = N (n = 9) | 2 | 7 |
| P = 0.038 | ||
Table 2 Cell cycle phase fractions of 29 gastric cancer tissues with or without MAD2 overexpression (mean ± SD)
| Phase fraction (%) | |||
| G0/G1 | S | G2/M | |
| MAD2 level | |||
| T > N (n = 20) | 80.8 ± 5.9 | 8.6 ± 7.0 | 10.6 ± 4.9 |
| T = N (n = 9) | 83.5 ± 7.4 | 9.9 ± 7.7 | 6.4 ± 4.0 |
| P = 0.301 | P = 0.657 | P = 0.033 | |
Table 3 DNA ploidy status of 32 gastric cancer tissues with or without MAD2 overexpression
| Diploidy | Aneuploidy | |
| MAD2 level | ||
| T > N (n = 23) | 10 | 13 |
| T = N (n = 9) | 4 | 5 |
| P = 1.000 | ||
Table 4 Relationships between elevated MAD2 levels and clinicopathological characteristics (mean ± SD)
| MAD2 level | |||
| T > N (n = 25) | T = N (n = 9) | P | |
| Age (yr) | 62.8 ± 10.3 | 66.4 ± 5.0 | 0.325 |
| Sex (male/female) | 19/6 | 6/3 | 0.586 |
| Site of tumor | 0.828 | ||
| Upper stomach | 4 | 2 | |
| Middle stomach | 6 | 2 | |
| Lower stomach | 14 | 4 | |
| Whole stomach | 1 | 1 | |
| Size of tumor (cm) | 7.3 ± 2.3 | 8.0 ± 2.9 | 0.470 |
| Grade of cell differentiation | 0.146 | ||
| Well differentiated | 1 | 0 | |
| Moderately differentiated | 13 | 8 | |
| Poorly differentiated | 11 | 1 | |
| Borrmann type | 0.664 | ||
| 0 | 2 | 0 | |
| 1 + 2 | 6 | 2 | |
| 3 + 4 | 17 | 7 | |
| Stromal reaction | 0.739 | ||
| Medullary type | 6 | 3 | |
| Intermediate type | 12 | 3 | |
| Schirrhous type | 7 | 3 | |
| Infiltration type | 0.475 | ||
| α | 4 | 2 | |
| β | 8 | 1 | |
| γ | 13 | 6 | |
| Lauren histological classification | 0.448 | ||
| Intestinal type | 13 | 3 | |
| Diffuse type | 12 | 6 | |
| Lymph node metastasis (Yes/No) | 15/10 | 6/3 | 1.000 |
| Lymphatic duct invasion (Yes/No) | 18/7 | 7/2 | 1.000 |
| Vascular invasion (Yes/No) | 2/23 | 1/8 | 1.000 |
| Liver metastasis (Yes/No) | 1/24 | 0/9 | 1.000 |
| Peritoneal dissemination (Yes/No) | 2/23 | 1/8 | 1.000 |
| Depth of cancer invasion | 0.738 | ||
| Mucosa, submucosa | 1 | 0 | |
| Propria muscle, subserosa | 5 | 1 | |
| Serosa | 18 | 8 | |
| Serosa (infiltration) exposed | 1 | 0 | |
| TNM stage | 0.932 | ||
| I | 3 | 1 | |
| II | 8 | 2 | |
| III | 8 | 3 | |
| IV | 6 | 3 | |
| Five-yr overall survival rate | 48.0% | 20.8% | 0.478 |
| Five-yr disease-free survival rate | 46.3% | 11.1% | 0.229 |
- Citation: Wu CW, Chi CW, Huang TS. Elevated level of spindle checkprotein MAD2 correlates with cellular mitotic arrest, but not with aneuploidy and clinicopathological characteristics in gastric cancer. World J Gastroenterol 2004; 10(22): 3240-3244
- URL: https://www.wjgnet.com/1007-9327/full/v10/i22/3240.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i22.3240