Effect of hepatitis B immunoglobulin on interruption of HBV intrauterine infection

Table 1 Clinical characteristics of pregnant women of each group

Characteristics	HBIG group (n = 57)	Control group (n = 55)
Age (yr)	26.9 ± 1.8	27.8 ± 2.8
Nationality of Han	57	55
Gravidity	1.5 ± 0.9	1.9 ± 1.2
Abortive parity	0.6 ± 0.7	0.7 ± 1.0
Gestational weeks	39.5 ± 1.9	39 ± 1.3
Rate of cesarean section	27 (47.4%)	25 (45.5%)
Threatened abortion	7	5
Threatened premature labour	2	2
Premature rupture of membrane	0	0
Pregnancy induced hypertension syndrome	1	1
Premature delivery	0	1
Postmature labour	0	0
Elderly primipara	0	0
Medical and surgical associated diseases	2	2
HBeAg positive rate	36 (63.2%)	28 (50.9%)
HBV DNA level (log10)	5.75 ± 2.98	5.54 ± 3.09

Table 2 Characters of neonatal HBV intrauterine infection

	Neonates n	HBsAg	HBeAg	HBcAb	HBeAb	HBsAb	HBV DNA	n	Intrauterine infection n (%)
Control group	55	+	-	+	+	-	-	2	15 (27.27)
		-	-	-	-	-	+	3
		-	-	-	+	-	+	3
		-	+	+	-	-	+	3
		-	-	+	+	-	+	4
HBIG group	57	+	-	+	+	-	-	1	6 (10.53)
		+	+	+	-	-	-	1
		-	-	+	-	-	+	4

Table 3 HBV DNA levels in blood of mothers at delivery and HBV intrauterine infection

HBV DNA grade	Mothers (n)	Intrauterine infection		Value of OR
		n	Percentage (%)
Grade 0 (< 105copies/mL)	26	0	0	...
Grade 1 (< 106copies/mL)	22	0	0	...
Grade 2 (< 107copies/mL)	15	2	13.33	1.00
Grade 3 (< 108copies/mL)	13	2	15.38	5.55
Grade 4 (< 109copies/mL)	32	15	46.88	26.91
Grade 5(< 1010copies/mL)	4	2	50.00	30.50

Table 4 Development indices of neonates and Apgar score (mean ± SD)

	Weight (kg)	Height (cm)	1-minute Apgar score
HBIG group	3.05 ± 0.25	48.0 ± 1.4	10 ± 0.0
Control group	3.04 ± 0.45	48.1 ± 1.5	9.9 ± 0.3