Chronic gastritis rat model and role of inducing factors

Table 1 L₈(2⁷) orthogonal test results of inflammation grades in stomachs of rats

Treatment factors	Triple orthogonal tests results
		Antrum			Body
A + B + C	2.10	1.83	2.00	1.67	1.60	1.64
A + B	1.67	1.50	1.63	1.30	1.40	1.38
A + C	2.10	2.10	1.83	1.67	1.64	1.67
A	1.50b	1.67b	1.75b	1.29b	1.25b	1.40b
B + C	1.17	1.25	1.00	1.00	1.08	0.90
B	0.75	0.75	0.83	0.60	0.67	0.63
C	1.25d	1.17d	1.00d	0.88d	1.00d	1.10d
Control	0.75	0.83	0.75	0.60	0.64	0.67

^bP < 0.01 vs the control,

^dP < 0.01 vs the control. Factor A: Com-bined intragastric treatments of 60% alcohol, 20 mmol/L so-dium deoxycholate and 0.5 g/L ammonia; Factor B: Treatment of forage containing low levels of vitamins; Factor C: Treat-ment of indomethacin.

Table 2 L₈(2⁷) orthogonal test results of thickness of lamina propria in stomachs of rats

Treatment factors	Triple orthogonal tests results (μm)
		Antrum			Body
A + B + C	40.0	38.5	36.5	310.0	290.0	305.0
A + B	43.5	41.5	45.0	383.5	283.5	338.5
A + C	46.5	36.5	36.5	311.5	313.5	325.0
A	43.5b	41.5b	45.0b	358.5	331.5	330.0
B + C	70.0	72.0	66.5	308.5	328.5	341.5
B	65.0	75.0	68.5	333.8	333.5	326.5
C	71.5	71.0	75.0	333.5	325.0	311.5
Control	66.5	71.5	75.0	300.0	310.0	313.5

^bP < 0.01 vs the control. Factor A: Combined intragastric treat-ments of 600 mL/L alcohol, 20 mmol/L sodium deoxycholate and 0.5 g/L ammonia; Factor B: Treatment of forage contain-ing low levels of vitamins; Factor C: Treatment of indomethacin.

Table 3 L₈(2⁷) orthogonal test results of changes of glands in gastric lamina propria of rats

Treatment factors	Triple orthogonal tests results
	Percentage ratio of pyloric gland			Parietal cell number in
	area to total lamina propria at			observed oxyntic glands
	gastric antrum			in gastric body
A + B + C	0.2188	0.3750	0.3125	12	10	13
A + B	0.3750	0.3000	0.3750	14	12	14
A + C	0.3650	0.3125	0.3333	11	11	12
A	0.3438b	0.3750b	0.3230b	14b	12b	15b
B + C	0.5688	0.5150	0.5725	28	23	25
B	0.5385	0.5625	0.5313	25	26	23
C	0.5750	0.5840	0.6500	26	23	27
Control	0.5250	0.6050	0.5893	25	29	23

^bP < 0.01 vs the control. Factor A: Combined intragastric treat-ments of 600 mL/L alcohol, 20 mmol/L sodium deoxycholate and 0.5 g/L ammonia; Factor B: Treatment of forage contain-ing low levels of vitamins; Factor C: Treatment of indomethacin.