Expansion of endothelial surface by an increase of vessel diameter during tumor angiogenesis in experimental hepatocellular and pancreatic cancer

Table 1 Summary of tumor models used in present study

	Pancreatic cance	Hepatocellular cancer
Tumor cell line	DSL6A	Morris hepatoma 3924A
Syngeneic strain	Lewis	ACI
Tumor inoculation	Solid tumor fragment	Cell suspension
Time after inoculation	6 wk	12 d

Table 2 Vessel density in normal and malignant tissue

Vessel density (n/mm2)	Healthy pancreas	Pancreatic cancer	P
Intravital microscopy	565 ± 89	116 ± 36	< 0.001
Immunohistochemistry	91 ± 22	35 ± 10	< 0.001

Table 3 Vessel density in normal and malignant liver tissue

Vessel density (n/mm2)	Healthy liver	Liver carcinoma	P
Intravital microscopy	689 ± 36	286 ± 32	< 0.01
Immunohistochemistry	196 ± 30	49 ± 13	< 0.01