Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance

Table 1 protein expression in gastric carcinoma

	n	MUC1				MUC2				MUC5AC				E-cadherin
		-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
Types of cancer		P = 0.005				P = 0.001				NS				NS
WMDTA	33	3	2	3	25	2	3	7	21	21	6	0	6	10	8	5	10
PDA	23	3	11	2	7	7	6	5	5	15	4	1	3	11	5	3	4
SRCC	31	9	10	2	10	6	9	10	6	14		5	8	15	8	4	4
MC	7	2	1	0	4	0	0	0	7	6	0	0	1	5	2	0	0
Age(yr)		P = 0.03				NS				NS				NS
4 0	19	5	4	2	8	3	6	5	5	12	2	2	3	10	7	1	1
> 40, ≤ 60	48	9	18	1	20	10	9	10	19	26	10	3	9	20	9	8	11
> 60	27	3	2	4	18	3	2	7	15	18	2	1	6	11	7	3	6
Sex		NS				NS				P = 0.02				NS
male	64	13	14	4	33	10	10	14	30	42	5	3	14	28	17	7	12
female	30	4	10	3	13	6	7	8	9	14	9	3	4	13	6	5	6
Location		NS				NS				NS				NS
Upper 1/3	13	0	4	1	8	1	2	0	10	12	0	0	1	3	4	1	5
Middle 1/3	23	6	6	0	11	4	3	6	10	12	3	2	6	11	7	2	3
Lower 1/3	58	11	14	6	27	11	12	16	19	32	11	4	11	27	12	9	10
Invasion		NS				NS				NS				NS
within mucosa & sub-mucosa	7	2	1	0	4	3	2	0	2	5	0	0	2	4	1	0	2
Muscular layer	19	5	7	1	6	5	4	6	4	9	1	3	6	9	3	5	2
Serosa	68	10	16	6	36	8	11	16	33	42	13	3	10	28	19	7	14
Metastasis to LN		P = 0.031				NS				NS				NS
No	40	9	14	10	7	9	9	11	11	25	4	3	8	20	8	5	7
Yes	54	8	10	7	29	7	8	11	28	31	10	3	10	21	15	7	11
Metastasis to other organs		NS				NS				NS				NS
No	70	14	19	7	30	13	12	18	27	42	7	5	16	32	19	8	11
Yes	24	3	5	0	16	3	5	4	12	14	7	1	2	9	4	4	7
Tumor size (cm)		P = 0.044				NS				NS				NS
≤ 3	29	9	4	4	12	9	6	6	8	17	5	0	7	12	7	3	7
3-6	52	4	17	3	28	5	10	15	22	29	9	5	9	20	15	6	11
> 6	13	4	3	0	6	2	1	1	9	10	0	1	2	9	1	3	0

NS: no significant difference; WMDTA: well and moderately differentiated tubular adenocarcinoma; PDA: Poorly differentiated adenocarcinoma; SRCC: Signet-ring cell; MC: mucinous carcinoma; LN: lymph node.