Endoscopic survey of esophageal cancer in a high-risk area of China

Table 1 Statistics of the residents of the 9 target villages enrolled in this survey

Village	Total population	Aged between 40-69 (yr %)	Contrain- dication	Expected population	Examined population	Survey rate (%)
Hebei Village	1184	304 (25.7)	29	275	220	80.0
Taichen Village	1648	412 (25.0)	39	373	287	76.9
Xichengji Village	1682	381 (22.7)	53	328	283	86.3
Zhonghao Village	699	183 (26.2)	23	160	130	81.3
Donghao Village	1860	494 (26.6)	26	468	208	44.4
Chejiao Village	1618	383 (23.7)	38	345	276	80.0
Bai Village	1679	415 (24.7)	27	388	284	73.2
Donghelan Village	1076	271 (25.2)	17	254	208	81.9
Xihelan Village	602	149 (24.8)	15	134	117	87.3
Total	12048	2992 (24.8)	305	2725	2013	73.8

The percentages in bracket indicate the rates of the population aged 40-69 years.

Table 2 Detection rates of the histologic changes in the esopha-gus (%)

Type	Male (%)	Female (%)	Total (%)
Normal squamous epithelium	308 (31.7)	392 (37.7)	700 (34.8)
Squamous epithelial acanthosis	19 (2.0)	19 (1.8)	38 (1.9)
Squamous epithelial atrophy	1 (0.1)	2 (0.2)	3 (0.1)
Esophagitis
Mild	337 (34.6)	366 (35.2)	703 (34.9)
Moderate	11 (1.1)	22 (2.1)	33 (1.6)
Severe	1 (0.1)	3 (0.3)	4 (0.2)
Dysplasia
Mild	114 (11.7)	58 (5.6)	172 (8.6)
Moderate	82 (8.4)	75 (7.2)	157 (7.8)
Severe	29 (3.0)	24 (2.3)	53 (2.6)
In situ carcinoma	25 (2.6)	25 (2.4)	50 (2.5)
Intramucosal carcinoma	2 (0.2)	2 (0.2)	4 (0.2)
Invasive carcinoma	5 (0.5)	9 (0.9)	14 (0.7)
Others	31 (3.2)	33 (3.2)	64 (3.2)
Total	973 (100.0)	1040 (100.0)	2013 (100.0)

Table 3 Age-related distribution of the incidence of pathological changes in esophagus

Type	Age [yr (%)]
	40-	45-	50-	55-	60-	65-69
Normal squamous epithelium	355 (44.8)	176 (38.4)	92 (28.6)	56 (24.9)	14 (9.4)	7 (10.4)
Squamous epithelial acanthosis	11 (1.4)	4 (0.9)	10 (3.1)	7 (3.1)	5 (3.4)	1 (1.5)
Squamous epithelial atrophy	1 (0.1)	1 (0.2)	1 (0.3)	-	-	-
Basal cell hyperplasia	6 (0.8)	6 (1.3)	3 (0.9)	1 (0.4)	2 (1.3)	-
Esophagitis
Mild	304 (38.4)	167 (36.5)	90 (28.0)	71 (31.6)	53 (35.6)	18 (26.9)
Moderate	17 (2.1)	2 (0.4)	9 (2.8)	4 (1.8)	1 (0.7)	-
Severe		1 (0.2)	2 (0.6)	1 (0.4)	-	-
Dysplasia
Mild	37 (4.7)	36 (7.9)	41 (12.7)	26 (11.6)	21 (14.1)	11 (16.4)
Moderate	19 (2.4)	30 (6.6)	43 (13.4)	26 (11.6)	26 (17.4)	13 (19.4)
Severe	12 (1.5)	12 (2.6)	12 (3.7)	6 (2.7)	9 (6.0)	2 (3.0)
In situ carcinoma	3 (0.4)	8 (1.7)	10 (3.1)	14 (6.2)	8 (5.4)	7 (10.4)
Intramucosal carcinoma	-	2 (0.4)	-	-	2 (1.3)	-
Invasive carcinoma	-	2 (0.4)	3 (0.9)	4 (1.8)	3 (2.0)	2 (3.0)
Others	27 (3.4)	11 (2.4)	6 (1.8)	9 (4.0)	5 (3.4)	6 (9.0)
Total	792 (100.0)	458 (100.0)	322 (100.0)	225 (100.0)	149 (100.0)	67 (100.0)

Table 4 Incidence of pathological changes detected histologi-cally in the cardia (%)

Type	Male (%)	Female (%)	Total (%)
Normal adenoepithelium	301 (31.0)	329 (31.7)	630 (31.4)
Non-atrophic gastritis	323 (33.2)	407 (39.1)	730 (36.3)
Atrophic gastritis	110 (11.3)	122 (11.7)	232 (11.5)
Dysplasia
Mild	36 (3.7)	15 (1.4)	51 (2.5)
Severe	12 (1.2)	5 (0.5)	17 (0.8)
Intramucosal adenocarcinoma	1 (0.1)	2 (0.2)	3 (0.1)
Invasive adenocarcinoma	12 (1.2)	5 (0.5)	17 (0.8)
Others	178 (18.3)	155 (14.9)	333 (16.5)
Total	973 (100.0)	1040 (100.0)	2013 (100.0)

Table 5 Age-related distribution of detection rates of pathological changes in gastric cardia

Type	Age [yr (%)]
	40-	45-	50-	55-	60-	65-
Normal adenoepithelium	295 (37.2)	156 (34.1)	81 (25.2)	61 (27.1)	27 (18.1)	10 (14.9)
Non-atrophic gastritis	319 (40.3)	169 (36.9)	116 (36.0)	60 (26.7)	47 (31.5)	19 (28.4)
Atrophic gastritis	90 (11.4)	45 (9.8)	38 (11.8)	34 (15.1)	14 (9.4)	11 (16.4)
Dysplasia
Mild	13 (1.6)	8 (1.7)	10 (3.1)	8 (3.6)	8 (5.4)	4 (6.0)
Severe	-	8 (1.7)	2 (0.6)	3 (1.3)	4 (2.7)	-
Intramucosal adenocarcinoma	-	-	1 (0.3)	-	1 (0.7)	1 (1.5)
Invasive adenocarcinoma	-	1(0.2)	1 (0.3)	3 (1.3)	5 (3.4)	7 (10.4)
Others	75 (9.5)	71 (15.5)	73 (22.6)	56 (24.9)	43 (28.9)	15 (22.4)
Total	792 (100.0)	458 (100.0)	322 (100.0)	225 (100.0)	149 (100.0)	67 (100.0)