Effects of zhaoyangwan on chronic hepatitis B and posthepatic cirrhosis

Table 1 Improvement of symptoms and signs in both groups before and after treatment

Symptoms and signs	Treated group			Control group			χ2	P
	BT	AT	DR(%)	BT	AT	AT
Fatigue	29	14	51.7	12	6	50	0.10	> 0.05
Abdominal distension	31	9	71	13	5	61.5	0.375	> 0.05
Nausea	12	7	41.7	8	6	25	0.586	> 0.05
Anorexia	23	6	73.9	11	4	63.6	0.379	> 0.05
Hepatic pain	17	10	41.2	7	5	28.6	0.336	> 0.05
Sallow complexion	14	4	71.4	5	3	40	1.564	> 0.05
Hepatomegaly	20	12	40	6	3	50	0.189	> 0.05
Splenomegaly	9	7	22.2	4	3	25	0.012	> 0.05
Percussion pain of liver	21	12	42.9	9	5	44.4	0.006	> 0.05

Table 2 Changes of T-cell sub-group and NK cell activity before and after treatment (%)

		n	CD3+	CD4+	CD8+	CD4+/CD8+	NK
reated group	BT	36	47.14 ± 4.76	41.56 ± 5.06	30.10 ± 3.03	1.41 ± 0.24	43.62 ± 5.92
	AT	36	57.81 ± 5.83	54.81 ± 5.64ab	23.07 ± 4.47ab	2.49 ± 0.72ab	56.69 ± 5.29ab
Control group	BT	14	39.93 ± 5.00	28.38 ± 3.40	23.38 ± 3.40	1.40 ± 0.18	40.36 ± 5.90
	AT	14	52.28 ± 7.18b	29.17 ± 1.86	29.17 ± 1.86	1.34 ± 0.88	59.40 ± 4.97b

^aThe treated group vs control group after treatment, P < 0.001,

^bResults after treatment vs those before treatment for both groups, P < 0.001.

Table 3 Changes of 5 serum complement elements before and after treatment (mg/L)

		n	C4	C1q	C3	BF	C9
Treated group	BT	36	339.68 ± 35.40	245.09 ± 47.11	842.13 ± 62.51	220.91 ± 32.84	746.28 ± 62.79
	AT	36	529.48 ± 42.49b	349.32 ± 35.01b	1 114.05 ± 218.22b	279.71 ± 52.86b	819.31 ± 103.17b
Control group	BT	14	331.84 ± 42.63	240.08 ± 25.32	838.54 ± 44.32	219.56 ± 25.08	715.06 ± 77.58
	AT	14	427.57 ± 112.18ab	238.35 ± 23.59a	843.89 ± 50.32a	225.08 ± 26.85a	732.08 ± 51.12a

^aThe treated group vs control group after treatment, P < 0.001,

^bResults after treatment vs those before treatment for both groups, P < 0.001.

Table 4 Changes of serum interferon concentration before and after treatment

	Case	BT	AT	t	P
	numbe
Treated group	13	156.25 ± 17.62	155.93 ± 19.76	0.046	> 0.05
Control group	8	143.27 ± 21.44	218.72 ± 63.34	3.193	< 0.05

After treatment, the serum interferon concentration of the two groups was significantly different (t = 2.723, P < 0.05).